Department of Medical Sciences, University of Turin, Turin, Italy -
Department of Medical Sciences, University of Turin, Turin, Italy.
Panminerva Med. 2018 Mar;60(1):29-34. doi: 10.23736/S0031-0808.18.03405-5. Epub 2018 Jan 25.
Fecal calprotectin (FC) is a calcium-binding protein with antimicrobic, imunomodulatory and antiproliferative properties that is mainly found in the cytoplasm of neutrophil granulocytes. During the last decades, FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. FC correlates with clinical scoring systems and endoscopic lesions in IBD and is considered a reliable biomarker for the prediction of clinical relapse or remission. However, FC elevation could be observed also in other gastrointestinal pathological conditions including infective colitis, microscopic colitis, eosinophilic colitis, adenomas and colorectal cancer. In addition, there are several non-pathological conditions that can lead to altered FC values. In this review, we aimed to point out individual, environmental and method-related factors that can affect FC measurement and thus its clinical interpretation.
粪便钙卫蛋白（FC）是一种钙结合蛋白，具有抗微生物、免疫调节和抗增殖作用，主要存在于中性粒细胞的细胞质中。在过去的几十年中，FC 已成为胃肠病学家和全科医生鉴别炎症性肠病（IBD）与肠易激综合征的一种越来越有用的工具。FC 与 IBD 的临床评分系统和内镜病变相关，被认为是预测临床复发或缓解的可靠生物标志物。然而，FC 升高也可见于其他胃肠道病理情况，包括感染性结肠炎、显微镜结肠炎、嗜酸性结肠炎、腺瘤和结直肠癌。此外，还有一些非病理情况也会导致 FC 值改变。在这篇综述中，我们旨在指出可能影响 FC 测量及其临床解释的个体、环境和方法相关因素。
