家庭式经颅直流电刺激（tDCS）在双相抑郁中的可接受性：个体观点的主题分析

Acceptability of Home-Based Transcranial Direct Current Stimulation (tDCS) in Bipolar Depression: Thematic Analysis of Individual Views.

作者信息

Rezaei Hakimeh, Woodham Rachel D, Ghazi-Noori Ali-Reza, Ritter Philipp, Bauer Michael, Young Allan H, Bramon Elvira, Fu Cynthia H Y

机构信息

Department of Psychiatry and Psychotherapy, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; School of Psychology, University of East London, Arthur Edwards Building, Water Lane, London, E15 4LZ, UK.

School of Psychology, University of East London, Arthur Edwards Building, Water Lane, London, E15 4LZ, UK.

出版信息

Res Sq. 2025 Apr 15:rs.3.rs-5967699. doi: 10.21203/rs.3.rs-5967699/v1.

DOI:10.21203/rs.3.rs-5967699/v1

PMID:40321750

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12047973/

Abstract

BACKGROUND

Acceptability is a multifaceted concept that reflects how a treatment is viewed, which impacts on patient engagement, adherence, and provider implementation. Transcranial direct current stimulation (tDCS) is emerging as a novel non-invasive treatment for bipolar depression. We developed a home-based protocol for tDCS which has demonstrated efficacy in unipolar and bipolar depression. We sought to explore the acceptability of home-based tDCS in bipolar depression.

METHODS

Participants were 35 (26 women) with bipolar disorder (mean age 47.37 years, SD ± 13.78) in a current depressive episode of at least moderate severity. tDCS was provided in a bifrontal montage 2 mA for 30 minutes in sessions over 6 weeks with real-time supervision. Acceptability was assessed in a questionnaire and individual interviews, conducted at two timepoints: baseline and post treatment. Individual interviews were analysed by thematic analysis.

RESULTS

Six main themes were found: helpfulness, side effects, burden, gratitude, ethicality and comparison to medications. The themes of gratitude and comparison with medications were novel in this group compared to unipolar depression.

CONCLUSION

Themes reflected high acceptability of tDCS treatment in bipolar depression and indicated strong interest in novel treatments in this population. Qualitative analysis can provide novel insights into individual experiences, understanding barriers to treatment, and offer guidance for improving clinical treatments.

TRIAL REGISTRATION

ClinicalTrials.gov: NCT05436613 registered on 23 June 2022 https//www.clinicaltrials.gov/study/NCT05436613.

摘要

背景

可接受性是一个多方面的概念，反映了对一种治疗方法的看法，这会影响患者的参与度、依从性以及医疗服务提供者的实施情况。经颅直流电刺激（tDCS）正在成为一种治疗双相抑郁症的新型非侵入性疗法。我们开发了一种基于家庭的tDCS方案，该方案已在单相和双相抑郁症中显示出疗效。我们试图探索基于家庭的tDCS在双相抑郁症中的可接受性。

方法

35名参与者（26名女性）患有双相情感障碍（平均年龄47.37岁，标准差±13.78），目前处于至少中度严重程度的抑郁发作期。在6周的疗程中，以双额叶组合方式提供2毫安的tDCS，每次30分钟，并进行实时监督。在两个时间点进行问卷调查和个人访谈来评估可接受性，这两个时间点分别是基线和治疗后。通过主题分析对个人访谈进行分析。