He Shuying, Lv Yuerong, Gao Zixian, Peng Liang
Department of Gastroenterology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou city, Guangdong Province, People's Republic of China.
Department of Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou city, Guangdong Province, People's Republic of China.
Int J Nanomedicine. 2025 Apr 30;20:5645-5659. doi: 10.2147/IJN.S500891. eCollection 2025.
The incidence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing because people's dietary habits are dominated by high caloric intake and sedentary lifestyles, leading to the accumulation of lipid, reactive oxygen species (ROS) and inflammation. However, treating MASH remains a challenge.
Two-dimensional (2D) niobium carbide (NbC) MXene nanoenzymes (MXenzymes) possess both antioxidant and anti-inflammatory properties and have attracted considerable attention in the tumor and engineering fields. The NbC MXenzyme was developed for MASH therapy and exhibited biosafety and antilipid peroxidation activity.
NbC reduced excessive ROS and proinflammatory cytokine levels through its antilipid peroxidation activities, resulting in the inhibition of hepatocyte lipid accumulation and inflammation in a methionine-choline-deficient diet (MCD)-induced murine MASH model. Mechanistically, NbC not only inhibited lipid accumulation and disrupted lipid metabolism in hepatocytes but also attenuated fatty acid-induced cell death by reducing intracellular ROS levels, which significantly promoted the polarization of M1 macrophages to M2 macrophages by alleviating oxidative stress and suppressing inflammatory factor expression.
The NbC MXenzyme can be used as a multifunctional bioactive material to alleviate hepatic steatosis and inflammation in MASH mice through its robust antioxidant and anti-inflammatory activities.
由于人们的饮食习惯以高热量摄入和久坐不动的生活方式为主，导致脂质、活性氧（ROS）积累和炎症，代谢功能障碍相关脂肪性肝炎（MASH）的发病率正在上升。然而，治疗MASH仍然是一项挑战。
二维（2D）碳化铌（NbC）MXene纳米酶（MXenzymes）具有抗氧化和抗炎特性，在肿瘤和工程领域引起了相当大的关注。开发NbC MXene纳米酶用于MASH治疗，并表现出生物安全性和抗脂质过氧化活性。
在蛋氨酸-胆碱缺乏饮食（MCD）诱导的小鼠MASH模型中，NbC通过其抗脂质过氧化活性降低了过量的ROS和促炎细胞因子水平，从而抑制了肝细胞脂质积累和炎症。从机制上讲，NbC不仅抑制肝细胞中的脂质积累并破坏脂质代谢，还通过降低细胞内ROS水平减轻脂肪酸诱导的细胞死亡，通过减轻氧化应激和抑制炎症因子表达，显著促进M1巨噬细胞向M2巨噬细胞极化。
NbC MXene纳米酶可作为一种多功能生物活性材料，通过其强大的抗氧化和抗炎活性减轻MASH小鼠的肝脂肪变性和炎症。
