Hu Xin, Xu Wenhao, Chen Xin, Zhao Xiaojie, Xu Xiaoguang, Peng Jing, Song Qi, Zhang Bingyuan, Zhang Min, Xuan Hongzhuan
College of Agriculture and Biology, Liaocheng University, Liaocheng 252059, China.
School of Physics Science and Information Engineering, Liaocheng University, Liaocheng 252059, China.
Biomed Opt Express. 2025 Mar 24;16(4):1546-1556. doi: 10.1364/BOE.554409. eCollection 2025 Apr 1.
Terahertz biosensors are employed to detect proteins in cancer cells to facilitate early diagnosis and monitoring of cancer treatments. By optimizing the design and functionality of black phosphorus-based sensors, it is possible to enhance their sensitivity and specificity for specific cancer biomarkers, leading to more accurate diagnostic outcomes. The application of the externally applied magnetic field and the 455 nm continuous-wave laser further augments the sensitivity of cellular responses to THz waves, with magnetic influences typically surpassing those of light fields by 10%-80%. Our results examine the photonic properties of black phosphorus, improve its interaction with terahertz waves, and create prototypes that can selectively identify proteins associated with cancer cells. Additionally, the stability and reproducibility of these sensors have been greatly improved, boosting their potential for widespread use in clinical environments.
太赫兹生物传感器用于检测癌细胞中的蛋白质,以促进癌症的早期诊断和治疗监测。通过优化基于黑磷的传感器的设计和功能,可以提高其对特定癌症生物标志物的灵敏度和特异性,从而获得更准确的诊断结果。外部施加的磁场和455纳米连续波激光的应用进一步提高了细胞对太赫兹波响应的灵敏度,磁影响通常比光场的影响高10%-80%。我们的研究结果考察了黑磷的光子特性,改善了其与太赫兹波的相互作用,并制造出了能够选择性识别与癌细胞相关蛋白质的原型。此外,这些传感器的稳定性和可重复性得到了极大提高,增强了它们在临床环境中广泛应用的潜力。