Yu Liu, Hao Liu, Meiqiong Tang, Jiaoqi Huang, Wei Liu, Jinying Dong, Xueping Chen, Weiling Fu, Yang Zhang
Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing 400038 China
Department of Laboratory Medicine, The Second Hospital Affiliated to Dalian Medical University Dalian 116023 China.
RSC Adv. 2019 Mar 22;9(17):9354-9363. doi: 10.1039/c8ra10605c.
Terahertz (THz = 10 Hz) spectroscopy has shown great potential in biomedical research due to its unique features, such as the non-invasive and label-free identification of living cells and medical imaging. In this review, we summarized the advantages and progresses achieved in THz spectroscopy technology for blood cell detection, cancer cell characterization, bacterial identification and biological tissue discrimination, further introducing THz imaging systems and its progress in tissue imaging. We also highlighted the biological effects of THz radiation during its biological applications and the existing challenges and strategies to accelerate future clinical applications. The future prospects for THz spectroscopy will focus on developing rapid, label-free, and convenient biosensors for point-of-care tests and THz imaging.
太赫兹（THz = 10赫兹）光谱由于其独特特性，如对活细胞的非侵入性和无标记识别以及医学成像，在生物医学研究中展现出了巨大潜力。在本综述中，我们总结了太赫兹光谱技术在血细胞检测、癌细胞表征、细菌识别和生物组织鉴别方面取得的优势和进展，还进一步介绍了太赫兹成像系统及其在组织成像方面的进展。我们还强调了太赫兹辐射在其生物应用过程中的生物效应，以及加速未来临床应用所面临的现有挑战和策略。太赫兹光谱的未来前景将聚焦于开发用于即时检测的快速、无标记且便捷的生物传感器以及太赫兹成像。
