Alghamdi Zeead M, Othman Sharifah A, Boumarah Dhuha N, Abdelmotaleb Mohammed Sabry, Alrashaid Farouk, Aljehani Yasser, Elbawab Hatem Y
Department of General Surgery, King Fahd Hospital of the University, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia.
Department of Obstetrics and Gynecology, King Fahd Hospital of the University, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Med Arch. 2025;79(1):15-19. doi: 10.5455/medarh.2025.79.15-19.
The centrally located portion of the thoracic cavity is called the mediastinum and consists of several essential organs. In the presence of various outcomes and prognostic indicators of mediastinal masses, meticulous diagnosis of these masses is considered crucial.
In this study, we analyzed all mediastinal masses observed clinically and pathologically at one institution over a period of ten years.
This is a retrospective, single-institution review of 94 patients with mediastinal masses, drawing on existing data recorded by the hospital. The study was carried out at the King Fahd University Hospital, Khobar, Saudi Arabia. Data was collected from 2009 to 2019. Participants were all patients with malignant or benign mediastinal masses admitted to the hospital, or diagnosed incidentally to have mediastinal masses during investigations for other reasons.
The mean age for developing a mediastinal mass was 33.89 ± 18.91 years of age. Most of the patients (69.1%) were symptomatic at presentation. Overall, (49.23%) of patients who were symptomatic at diagnosis had a malignant mass. Concerning pathologic diagnosis and presentation of the patient (symptomatic versus asymptomatic), there was a significant positive relationship between pathologic diagnosis and symptoms with a P value of 0.020. In our study, only 5.15% of cases experienced recurrence.
This study provides a great understanding of mediastinal tumor biology and the role of both radiotherapy and chemotherapy in increasing the survival rates of patients suffering from similar malignant conditions.
胸腔中央部分称为纵隔，由几个重要器官组成。鉴于纵隔肿块存在多种转归和预后指标，对这些肿块进行细致诊断至关重要。
在本研究中，我们分析了某机构在十年期间临床和病理观察到的所有纵隔肿块。
这是一项对94例纵隔肿块患者的回顾性单机构研究，利用医院记录的现有数据。该研究在沙特阿拉伯胡拜尔法赫德国王大学医院开展。数据收集时间为2009年至2019年。参与者为所有入院时患有恶性或良性纵隔肿块的患者，或在因其他原因进行检查时偶然被诊断为纵隔肿块的患者。
发生纵隔肿块的平均年龄为33.89±18.91岁。大多数患者（69.1%）在就诊时出现症状。总体而言，诊断时有症状的患者中（49.23%）患有恶性肿块。关于患者的病理诊断和表现（有症状与无症状），病理诊断与症状之间存在显著正相关，P值为0.020。在我们的研究中，只有5.15%的病例出现复发。
本研究极大地增进了对纵隔肿瘤生物学以及放疗和化疗在提高患有类似恶性疾病患者生存率方面作用的理解。
