Shaebth Laila Jasim, Naser Hassan Hachim, Nacim Louhichi
Department of Biology, Faculty of Science, University of Sfax, Sfax, Tunisia.
Technical Institute of Al-Diwaniyah, Al-Furat Al-Awsat Technical University, Diwaniyah, Iraq.
Pan Afr Med J. 2025 Jan 13;50:25. doi: 10.11604/pamj.2025.50.25.43995. eCollection 2025.
oropharyngeal candidiasis, commonly known as oral thrush, is a fungal infection caused by candida species, especially Candida albicans. With the onset of COVID-19, concerns have arisen about a possible link between the severity of COVID-19 infections and the presence of oropharyngeal candidiasis in patients. The aim to study the frequency of oropharyngeal candidiasis in COVID-19 patients and identify associated risk factors.
a cross-sectional study involving 100 COVID-19 patients was conducted at Al-Diwaniyah Hospital in Iraq. Samples were collected using blood tests and oropharyngeal tampons to diagnose oropharyngeal candidiasis. The mean age of the study population was 55.3 years (SD±12.4), with 60% male and 40% female. The data was analyzed using IBM SPSS software version 22, focusing on the correlation between the severity of COVID-19 and the occurrence of candidiasis.
among the 100 patients, 30 (30%) were diagnosed with oropharyngeal candidiasis. In patients with severe COVID-19 (45%) symptoms, the prevalence was significantly higher than in patients with mild (15%) and moderate (25%) symptoms (p=0.002). In addition, patients with candidiasis (CRP: 12.5 mg/l) had significantly higher mean levels of C-reactive protein (CRP: 12.5 mg/l) than patients without candidiasis (CRP: 6.8 mg/l, p < 0.001). Other risk factors identified included long-term hospitalization (mean duration of patients with candidiasis 12 days vs. 7 days without patients, p=0.005) and use of corticosteroids (70% of patients with candidiasis vs. 40% without, p=0.01).
the results show that oropharyngeal candidiasis is common among COVID-19 patients, especially those with severe infections, with a prevalence rate of 45%. The study emphasizes the importance of monitoring fungal infections in COVID-19 patients and the need for early diagnosis and treatment to improve patient outcomes. These findings are supported by the significant differences in prevalence and inflammatory markers observed in the study.
口腔念珠菌病，通常称为鹅口疮，是一种由念珠菌属引起的真菌感染，尤其是白色念珠菌。随着新冠疫情的爆发，人们开始关注新冠感染的严重程度与患者口腔念珠菌病之间可能存在的联系。本研究旨在探讨新冠患者口腔念珠菌病的发生率，并确定相关危险因素。
在伊拉克迪瓦尼亚医院对100例新冠患者进行了一项横断面研究。通过血液检测和口腔拭子采集样本以诊断口腔念珠菌病。研究人群的平均年龄为55.3岁（标准差±12.4），男性占60%，女性占40%。使用IBM SPSS 22软件对数据进行分析，重点关注新冠严重程度与念珠菌病发生之间的相关性。
100例患者中，30例（30%）被诊断为口腔念珠菌病。新冠症状严重的患者（45%）患病率显著高于症状轻微（15%）和中度（25%）的患者（p=0.002）。此外，患有念珠菌病的患者（C反应蛋白：12.5mg/l）的C反应蛋白平均水平显著高于未患念珠菌病的患者（C反应蛋白：6.8mg/l，p<0.001）。确定的其他危险因素包括长期住院（患念珠菌病患者的平均住院时间为12天，未患念珠菌病患者为7天，p=0.005）和使用皮质类固醇（患念珠菌病患者中有70%使用，未患念珠菌病患者中有40%使用，p=0.01）。
结果表明，口腔念珠菌病在新冠患者中很常见，尤其是那些严重感染的患者，患病率为45%。该研究强调了监测新冠患者真菌感染的重要性，以及早期诊断和治疗以改善患者预后的必要性。研究中观察到的患病率和炎症标志物的显著差异支持了这些发现。
