Department of Microbiology, Lokmanya Tilak Municipal Medical College & General Hospital, Sion, Mumbai 400 022, India.
J Med Microbiol. 2014 Apr;63(Pt 4):518-521. doi: 10.1099/jmm.0.060236-0. Epub 2014 Jan 20.
Mucocutaneous and cutaneous candidiasis, though common in children, is often under-reported. The prevalence of Candida dubliniensis in causing these infections in this age group is also largely unknown. A prospective epidemiological cross-sectional study for candidiasis was performed in paediatric patients clinically suspected of candidiasis with oropharyngeal lesions (75 patients), cutaneous lesions (18 patients) and lesions at both sites (2 patients). Candida species were identified by conventional tests. For C. dubliniensis, chlamydospore production, growth on tobacco agar and growth at 45 °C were performed. Nine isolates were confirmed at a reference centre. The rates of candidiasis were 77.3 % (58 out of 75 patients clinically suspected of candidiasis) and 83.3 % (15/18) in oropharyngeal and cutaneous lesions respectively, and 1 of the 2 children with lesions at both sites was diagnosed as having chronic mucocutaneous candidiasis due to C. dubliniensis. The commonest species isolated was Candida albicans, in 41 (70.7 %) patients with oropharyngeal candidiasis and 11 (73.3 %) with cutaneous lesions; C. dubliniensis was isolated from 11 and 3 children respectively. In the paediatric population, C. albicans predominates in mucocutaneous and cutaneous candidiasis, with C. dubliniensis also contributing substantially.
黏膜皮肤和皮肤念珠菌病虽然在儿童中很常见，但往往报告不足。在该年龄组中，导致这些感染的杜宾酵母属的流行情况也知之甚少。对临床上疑似有口腔病变（75 例患者）、皮肤病变（18 例患者）和两个部位均有病变（2 例患者）的念珠菌病的儿科患者进行了一项前瞻性的、流行病学的、横断面研究。通过常规检测方法鉴定念珠菌种。对于杜宾酵母属，检测厚垣孢子的产生、在烟草琼脂上的生长情况以及在 45°C 下的生长情况。在参考中心确认了 9 个分离株。在临床上疑似念珠菌病的 75 例患者中，念珠菌病的发生率为 77.3%（58 例），口腔和皮肤病变的发生率分别为 83.3%（15/18），在两个部位都有病变的 2 例患儿中，1 例被诊断为杜宾酵母属引起的慢性黏膜皮肤念珠菌病。最常见的分离株是白色念珠菌，在 41 例口腔念珠菌病患者（70.7%）和 11 例皮肤念珠菌病患者（73.3%）中均有分离；杜宾酵母属分别从 11 例和 3 例患儿中分离到。在儿科人群中，白色念珠菌在黏膜皮肤和皮肤念珠菌病中占主导地位，而杜宾酵母属也有很大的贡献。
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