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肝豆状核变性的精神症状表现:一种具有不寻常表现的罕见疾病。

Psychiatric Presentation of Wilson's Disease: A Rare Disease With an Unusual Manifestation.

作者信息

Baptista Inês, Alves Patrick

机构信息

Psychiatry, Centro Hospitalar São João, Porto, PRT.

出版信息

Cureus. 2025 Apr 3;17(4):e81645. doi: 10.7759/cureus.81645. eCollection 2025 Apr.

DOI:10.7759/cureus.81645
PMID:40322335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12048889/
Abstract

Wilson's disease is a rare disorder characterized by the accumulation of copper in multiple organs. Psychiatric symptoms are somewhat common but can take many different forms, which complicates their identification. We present a case where suicidal ideation and severe sleep disturbance were the central symptoms of the initial presentation. This case shows how psychiatric symptoms in uncompensated Wilson's disease can look like and how they are managed, as well as a psychological perspective into therapy nonadherence in chronic illness.

摘要

威尔逊氏病是一种罕见的疾病,其特征是铜在多个器官中蓄积。精神症状较为常见,但可能有多种不同形式,这使得它们的识别变得复杂。我们报告一例以自杀观念和严重睡眠障碍为首发主要症状的病例。该病例展示了失代偿性威尔逊氏病的精神症状表现及处理方式,以及从心理学角度探讨慢性病治疗依从性问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c03/12048889/88be444a980d/cureus-0017-00000081645-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c03/12048889/88be444a980d/cureus-0017-00000081645-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c03/12048889/88be444a980d/cureus-0017-00000081645-i01.jpg

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Psychiatric Presentation of Wilson's Disease: A Rare Disease With an Unusual Manifestation.肝豆状核变性的精神症状表现:一种具有不寻常表现的罕见疾病。
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本文引用的文献

1
Chelation therapy in liver diseases of childhood: Current status and response.儿童肝脏疾病中的螯合疗法:现状与反应
World J Hepatol. 2021 Nov 27;13(11):1552-1567. doi: 10.4254/wjh.v13.i11.1552.
2
Adherence to treatment, a challenge even in treatable metabolic rare diseases: A cross sectional study of Wilson's disease.治疗依从性,即使在可治疗的代谢性罕见病中也是一个挑战:一项对肝豆状核变性的横断面研究。
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3
Persistence with treatment for Wilson disease: a retrospective study.
Wilson 病治疗的持续性:一项回顾性研究。
BMC Neurol. 2019 Nov 12;19(1):278. doi: 10.1186/s12883-019-1502-4.
4
Social and demographic characteristics of a Polish cohort with Wilson disease and the impact of treatment persistence.波兰肝豆状核变性队列的社会人口学特征及治疗持续性的影响。
Orphanet J Rare Dis. 2019 Jul 5;14(1):167. doi: 10.1186/s13023-019-1133-2.
5
Wilson's disease: A 2017 update.肝豆状核变性:2017 年更新版
Clin Res Hepatol Gastroenterol. 2018 Dec;42(6):512-520. doi: 10.1016/j.clinre.2018.03.007. Epub 2018 Apr 4.
6
Psychiatric aspects of Wilson disease: a review.Wilson 病的精神科方面:综述。
Gen Hosp Psychiatry. 2014 Jan-Feb;36(1):53-62. doi: 10.1016/j.genhosppsych.2013.08.007. Epub 2013 Oct 9.
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Neurological Wilson disease in children: a three years experience from Multan.儿童神经型威尔逊病:来自木尔坦的三年经验
J Pak Med Assoc. 2011 Aug;61(8):743-8.
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Neuropsychiatric aspects of treated Wilson's disease.治疗后 Wilson 病的神经精神方面。
Parkinsonism Relat Disord. 2009 Dec;15(10):772-5. doi: 10.1016/j.parkreldis.2009.01.010. Epub 2009 Jun 25.
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Psychiatric manifestations in Wilson's disease: a cross-sectional analysis.肝豆状核变性的精神症状:一项横断面分析。
J Neuropsychiatry Clin Neurosci. 2008 Winter;20(1):81-5. doi: 10.1176/jnp.2008.20.1.81.
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Wilson disease: description of 282 patients evaluated over 3 decades.威尔逊氏病:对282例患者长达30年的评估描述。
Medicine (Baltimore). 2007 Mar;86(2):112-121. doi: 10.1097/MD.0b013e318045a00e.