Unraveling the Mystery: A Report of a Rare Case of Whipple's Disease Diagnosed After Months of Unexplained Symptoms.

Whipple's disease is a rare, chronic infectious condition with a highly variable presentation, often manifesting as arthralgia, diarrhea, and abdominal pain, resembling other gastrointestinal and rheumatologic disorders. As a result, diagnosis is often challenging and frequently delayed for three to seven years after symptom onset. Here, we present a case of a 61-year-old man who experienced abdominal distension, nausea, 18 kg weight loss (25% body weight), and diarrhea for six months. After an extensive workup, including endoscopies, imaging, and laboratory tests, a diagnosis of Whipple's disease was confirmed based on duodenal biopsy showing periodic acid-Schiff (PAS)-positive macrophages. The diagnostic process took three months, underscoring the difficulty in identifying this rare, unusual condition. Treatment was guided by more recent discoveries regarding the susceptibility of This case highlights the importance of maintaining a high clinical suspicion of Whipple's disease in patients with unexplained symptoms.