Stratford R E, Lee V H
J Pharm Sci. 1985 Jul;74(7):731-4. doi: 10.1002/jps.2600740707.
Aminopeptidase activity in the corneal epithelium and the conjunctiva of the albino rabbit eye was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-beta-naphthylamide as substrates. This was compared with the aminopeptidase activity in the duodenum, jejunum, and ileum. The two ocular tissues were found to be 5-15% as active as the ileum in aminopeptidase activity. There was indirect evidence that the dominant aminopeptidase in the corneal epithelium is different from that in the conjunctiva, suggesting that further studies are warranted to investigate the possibility of delivering certain peptides systemically via the conjunctiva without simultaneously exposing the intraocular tissues to these peptides.
以L-亮氨酸-、L-丙氨酸-和L-精氨酸-4-甲氧基-β-萘酰胺作为底物，测定了白化兔眼角膜上皮和结膜中的氨肽酶活性。并将其与十二指肠、空肠和回肠中的氨肽酶活性进行比较。结果发现，这两种眼组织的氨肽酶活性仅为回肠的5%-15%。有间接证据表明，角膜上皮中的主要氨肽酶与结膜中的不同，这表明有必要进一步研究通过结膜全身递送某些肽的可能性，同时又不使眼内组织暴露于这些肽。
