Stratford R E, Lee V H
Curr Eye Res. 1985 Sep;4(9):995-9. doi: 10.3109/02713689509000007.
Ocular aminopeptidase activity in the albino rabbit was determined using L-leucine-, L-alanine-, and L-arginine-4-methoxy-2-naphthylamide as substrates. The corneal epithelium and the iris-ciliary body were found to be the most active, followed by, in turn, conjunctiva and corneal stroma, lens and aqueous humor, and lastly tears. The pattern of substrate hydrolysis suggests that a common dominant aminopeptidase is present in these tissues except the conjunctiva. While the role of these peptidases in ocular physiology is unknown, they may play a role in limiting the entry of topically applied peptides into the eye.
使用L-亮氨酸-、L-丙氨酸-和L-精氨酸-4-甲氧基-2-萘基酰胺作为底物，测定了白化兔的眼氨基肽酶活性。发现角膜上皮和虹膜睫状体活性最高，依次为结膜和角膜基质、晶状体和房水，最后是眼泪。底物水解模式表明，除结膜外，这些组织中存在一种共同的主要氨基肽酶。虽然这些肽酶在眼生理学中的作用尚不清楚，但它们可能在限制局部应用的肽进入眼内方面发挥作用。
