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Relax, but Don't Forget to Breathe: Ictal Central Apnea and SUDEP.放松，但别忘了呼吸：发作性中枢性呼吸暂停与癫痫性猝死。
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A few thoughts: get outside, slow down, take a nap, and don't forget to breathe.几点想法：到户外去，放慢脚步，小睡一会儿，别忘了呼吸。
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本文引用的文献

1
Diaphragm relaxation causes seizure-related apnoeas in chronic and acute seizure models in rats.在大鼠的慢性和急性癫痫发作模型中，膈肌松弛会导致与癫痫发作相关的呼吸暂停。
Neurobiol Dis. 2024 Dec;203:106735. doi: 10.1016/j.nbd.2024.106735. Epub 2024 Nov 14.
2
Respiratory activity during seizures induced by pentylenetetrazole.戊四氮诱发癫痫发作时的呼吸活动。
Respir Physiol Neurobiol. 2024 May;323:104229. doi: 10.1016/j.resp.2024.104229. Epub 2024 Feb 1.
3
Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.阿片类药物引起呼吸抑制的神经机制：我们目前的理解。
J Neurophysiol. 2021 May 1;125(5):1899-1919. doi: 10.1152/jn.00017.2021. Epub 2021 Apr 7.
4
Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy.癫痫性猝死的小鼠模型中，惊厥后死亡与强直期呼吸暂停相关。
Ann Neurol. 2021 May;89(5):1023-1035. doi: 10.1002/ana.26053. Epub 2021 Mar 6.
5
Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood.听觉性惊厥作为癫痫猝死的模型：四种近交系小鼠从幼年到成年的比较研究。
Epilepsia. 2020 Feb;61(2):342-349. doi: 10.1111/epi.16432. Epub 2020 Jan 24.
6
Effect of monoamine reuptake inhibition and α blockade on respiratory arrest and death following electroshock-induced seizures in mice.单胺再摄取抑制和α阻断对电休克诱导的小鼠惊厥后呼吸停止和死亡的影响。
Epilepsia. 2019 Mar;60(3):495-507. doi: 10.1111/epi.14652. Epub 2019 Feb 5.
7
Breathing matters.呼吸至关重要。
Nat Rev Neurosci. 2018 Jun;19(6):351-367. doi: 10.1038/s41583-018-0003-6.
8
Severe peri-ictal respiratory dysfunction is common in Dravet syndrome.Dravet 综合征患者常出现严重的发作期呼吸功能障碍。
J Clin Invest. 2018 Mar 1;128(3):1141-1153. doi: 10.1172/JCI94999. Epub 2018 Feb 12.
9
Congenital central hypoventilation syndrome: An overview of etiopathogenesis, associated pathologies, clinical presentation, and management.先天性中枢性低通气综合征：病因发病机制、相关病变、临床表现及治疗概述
Auton Neurosci. 2018 Mar;210:1-9. doi: 10.1016/j.autneu.2017.11.003. Epub 2017 Nov 13.
10
Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study.癫痫监测单元中心跳呼吸骤停的发生率和机制（MORTEMUS）：一项回顾性研究。
Lancet Neurol. 2013 Oct;12(10):966-77. doi: 10.1016/S1474-4422(13)70214-X. Epub 2013 Sep 4.

Relax, but Don't Forget to Breathe: Ictal Central Apnea and SUDEP.

作者信息

Wenker Ian C

机构信息

Department of Anesthesiology, University of Virginia Health System.

出版信息

Epilepsy Curr. 2025 Apr 30:15357597251335680. doi: 10.1177/15357597251335680.

DOI:10.1177/15357597251335680
PMID:40322482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12043610/
Abstract
摘要