Dwivedi Sourabh, Gaikwad Kapila, Ansari Yar Mohammad, Dwivedi Pratiksha Pandey, Sharma Shikhar
Department of Biochemistry, Shyam Shah Medical College, Rewa, Madhya Pradesh, India.
Department of Microbiology, Rajmata Shrimati Devendra Kumari Singhdeo Government Medical College, Ambikapur, Chhattisgarh, India.
Bioinformation. 2025 Feb 28;21(2):137-144. doi: 10.6026/973206300210137. eCollection 2025.
Scrub typhus is a febrile illness caused by through trombiculid mite, bite . It is often unrecognized due to its vague symptoms. It is prevalent in the Rewa region of Madhya Pradesh, India. Therefore, it is of interest to assess hepatic dysfunction and to establish the association between liver function test parameters and disease severity in confirmed Scrub typhus cases. Hence, 50 IgM ELISA positive cases from July to September 2024 at Shyam Shah Medical College, Rewa were studied. Data were analysed using IBM SPSS 25 software, with Spearman's correlation used to relate severity, liver function test parameters and fever duration. The average fever duration was 6.22 days, with 80% of patients showing serum glutamate oxaloacetate transaminase and 70% showing serum glutamate pyruvate transaminase abnormalities. Thus, there was a correlation between disease severity and liver dysfunction, with moderate injury in 62% and severe injury in 38% of patients.
恙虫病是一种由恙螨叮咬引起的发热性疾病。由于其症状不明确，常常未被识别。它在印度中央邦雷瓦地区流行。因此，评估恙虫病确诊病例的肝功能障碍，并确定肝功能测试参数与疾病严重程度之间的关联具有重要意义。因此，对2024年7月至9月在雷瓦市希亚姆·沙阿医学院确诊的50例IgM ELISA阳性病例进行了研究。使用IBM SPSS 25软件对数据进行分析，采用Spearman相关性分析来关联疾病严重程度、肝功能测试参数和发热持续时间。平均发热持续时间为6.22天，80%的患者血清谷草转氨酶异常，70%的患者血清谷丙转氨酶异常。因此，疾病严重程度与肝功能障碍之间存在相关性，62%的患者为中度损伤，38%的患者为重度损伤。
