Prakash John Antony Jude
Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India,
Res Rep Trop Med. 2017 Aug 7;8:73-83. doi: 10.2147/RRTM.S105602. eCollection 2017.
Scrub typhus is an acute febrile illness in the "tsutsugamushi triangle", transmitted by chiggers that can be treated effectively if detected early. Laboratory testing, including molecular and serological assays, is needed for confirming the diagnosis, especially in the absence of the pathognomonic eschar. In this review, factors that play a role in disease occurrence and clinical clues for diagnosis, in addition to risk factors contributing to disease severity, including mortality, are discussed in detail. Moreover, issues related to diagnostic assays, treatment, and mixed infections are also enumerated and described.
恙虫病是发生在“恙虫病东方体三角区”的一种急性发热性疾病，由恙螨传播，如果早期发现可有效治疗。确诊需要进行实验室检测，包括分子检测和血清学检测，尤其是在没有特征性焦痂的情况下。在这篇综述中，详细讨论了在疾病发生中起作用的因素、诊断的临床线索，以及导致疾病严重程度（包括死亡率）的危险因素。此外，还列举并描述了与诊断检测、治疗及混合感染相关的问题。
