微小RNA在戊型肝炎病毒慢性感染中的作用
Role of microRNAs in chronic hepatitis E viral infection.
作者信息
Shafat Zoya, Ahmed Murshad, Farooqui Anam, Khan Nazim, Parveen Shama
机构信息
Department of Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
出版信息
Bioinformation. 2025 Feb 28;21(2):240-252. doi: 10.6026/973206300210240. eCollection 2025.
Abstract
Hepatitis E virus (HEV) is an emerging zoonotic pathogen and it is associated with chronic hepatitis E virus infection (CHE) in immuno-suppressed patients due to failure of viral clearance. A network of the CHE-associated-differentially expressed genes (DEGs) is known. Hence, a comprehensive assessment of the known protein-protein interaction (PPI) network is of interest. After network clustering, the hub gene-associated microRNAs (miRNAs) were explored and subsequently, these identified miRNAs (miR-129-2-3p, miR-130a-3p, miR-138-5p, miR-212-3p, miR-221-3p, miR-27b-3p and miR-29c-3p) were undertaken for enrichment analysis. It should be noted that these miRNAs are significantly associated with Hepatitis E virus infection for further validation and analysis.
摘要
戊型肝炎病毒（HEV）是一种新出现的人畜共患病原体，在免疫抑制患者中，由于病毒清除失败，它与慢性戊型肝炎病毒感染（CHE）相关。已知一个与CHE相关的差异表达基因（DEG）网络。因此，对已知的蛋白质-蛋白质相互作用（PPI）网络进行全面评估具有重要意义。在网络聚类后，探索了与枢纽基因相关的微小RNA（miRNA），随后，对这些鉴定出的miRNA（miR-129-2-3p、miR-130a-3p、miR-138-5p、miR-212-3p、miR-221-3p、miR-27b-3p和miR-29c-3p）进行了富集分析。应该指出的是，这些miRNA与戊型肝炎病毒感染显著相关，有待进一步验证和分析。
相似文献
1
Role of microRNAs in chronic hepatitis E viral infection.微小RNA在戊型肝炎病毒慢性感染中的作用
Bioinformation. 2025 Feb 28;21(2):240-252. doi: 10.6026/973206300210240. eCollection 2025.
2
Integrative Multiomics and Regulatory Network Analyses Uncovers the Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in Hepatitis E Virus Infection.整合多组学和调控网络分析揭示 OAS3、TRAFD1、miR-222-3p 和 miR-125b-5p 在戊型肝炎病毒感染中的作用。
Genes (Basel). 2022 Dec 23;14(1):42. doi: 10.3390/genes14010042.
3
Differentially expressed genes and miRNAs in female osteoporosis patients.女性骨质疏松症患者差异表达的基因和 miRNA。
Medicine (Baltimore). 2022 Jul 15;101(28):e29856. doi: 10.1097/MD.0000000000029856.
4
A Next-Generation Sequencing of Plasma Exosome-Derived microRNAs and Target Gene Analysis with a Microarray Database of Thermally Injured Skins: Identification of Blood-to-Tissue Interactions at Early Burn Stage.血浆外泌体衍生的微小RNA的下一代测序及热损伤皮肤微阵列数据库的靶基因分析：早期烧伤阶段血组织相互作用的鉴定
J Inflamm Res. 2021 Dec 10;14:6783-6798. doi: 10.2147/JIR.S343956. eCollection 2021.
5
Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis.腹膜液改变了子宫内膜异位症患者的子宫内膜和异位症细胞中的 microRNA 表达谱。
Hum Reprod. 2015 Oct;30(10):2292-302. doi: 10.1093/humrep/dev204. Epub 2015 Aug 25.
6
The expression of miR-125b-5p is increased in the serum of patients with chronic hepatitis B infection and inhibits the detection of hepatitis B virus surface antigen.慢性乙型肝炎感染患者血清中miR-125b-5p表达升高，并抑制乙型肝炎病毒表面抗原的检测。
J Viral Hepat. 2016 May;23(5):330-9. doi: 10.1111/jvh.12522. Epub 2016 Feb 29.
7
Identification of miRNAs associated with dendritic cell dysfunction during acute and chronic hepatitis B virus infection.鉴定与急性和慢性乙型肝炎病毒感染期间树突状细胞功能障碍相关的 miRNAs。
J Med Virol. 2021 Jun;93(6):3697-3706. doi: 10.1002/jmv.26629. Epub 2020 Nov 10.
8
SIV Infection Regulates Compartmentalization of Circulating Blood Plasma miRNAs within Extracellular Vesicles (EVs) and Extracellular Condensates (ECs) and Decreases EV-Associated miRNA-128.SIV 感染调节循环血浆 miRNA 在细胞外囊泡（EVs）和细胞外凝聚物（ECs）中的区室化，并降低 EV 相关 miRNA-128。
Viruses. 2023 Feb 24;15(3):622. doi: 10.3390/v15030622.
9
Aberrant expression of two miRNAs promotes proliferation, hepatitis B virus amplification, migration and invasion of hepatocellular carcinoma cells: evidence from bioinformatic analysis and experimental validation.两种微小RNA的异常表达促进肝癌细胞的增殖、乙型肝炎病毒扩增、迁移和侵袭：来自生物信息学分析和实验验证的证据
PeerJ. 2020 Apr 29;8:e9100. doi: 10.7717/peerj.9100. eCollection 2020.
10
Global microRNA expression profiling in the liver biopsies of hepatitis B virus-infected patients suggests specific microRNA signatures for viral persistence and hepatocellular injury.全球乙型肝炎病毒感染患者肝活检中的 microRNA 表达谱分析表明，特定的 microRNA 特征与病毒持续存在和肝细胞损伤有关。
Hepatology. 2018 May;67(5):1695-1709. doi: 10.1002/hep.29690. Epub 2018 Apr 1.
引用本文的文献
1
Differential miRNA signatures in Hepatitis E Virus Infection: Insights into acute, chronic, and pregnancy-related outcomes.戊型肝炎病毒感染中的差异miRNA特征：对急性、慢性及妊娠相关结局的见解。
Eur J Clin Microbiol Infect Dis. 2025 Jul 14. doi: 10.1007/s10096-025-05207-4.
本文引用的文献
1
Identification of key candidates associated with chronic hepatitis E viral infection.与戊型肝炎病毒慢性感染相关的关键候选物的鉴定
Bioinformation. 2025 Jan 31;21(1):66-77. doi: 10.6026/973206300210066. eCollection 2025.
2
Amino acid pattern reveals multi-functionality of ORF3 protein from HEV.氨基酸模式揭示了戊型肝炎病毒ORF3蛋白的多功能性。
Bioinformation. 2024 Feb 29;20(2):121-135. doi: 10.6026/973206300200121. eCollection 2024.
3
Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid.戊型肝炎病毒开放阅读框2中的内在无序性：一种具有病毒衣壳以外多种功能的蛋白质。
J Genet Eng Biotechnol. 2023 Mar 16;21(1):33. doi: 10.1186/s43141-023-00477-x.
4
Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection.特定血浆 microRNA 特征与戊型肝炎病毒感染的临床结局相关。
Microbiol Spectr. 2023 Feb 14;11(1):e0466422. doi: 10.1128/spectrum.04664-22. Epub 2023 Jan 25.
5
MiR-29c inhibits HCV replication activation of type I IFN response by targeting STAT3 in JFH-1-infected Huh7 cells.在JFH-1感染的Huh7细胞中，miR-29c通过靶向STAT3抑制丙型肝炎病毒（HCV）复制及I型干扰素反应的激活。
RSC Adv. 2018 Feb 20;8(15):8164-8172. doi: 10.1039/c7ra12815k. eCollection 2018 Feb 19.
6
microRNA-27b regulates hepatic lipase enzyme LIPC and reduces triglyceride degradation during hepatitis C virus infection.microRNA-27b 调控肝脂肪酶 LIPC，减少丙型肝炎病毒感染期间的甘油三酯降解。
J Biol Chem. 2022 Jun;298(6):101983. doi: 10.1016/j.jbc.2022.101983. Epub 2022 Apr 25.
7
Decoding the codon usage patterns in Y-domain region of hepatitis E viruses.解析戊型肝炎病毒Y结构域区域的密码子使用模式。
J Genet Eng Biotechnol. 2022 Apr 11;20(1):56. doi: 10.1186/s43141-022-00319-2.
8
MiR-129-2-3p Inhibits Esophageal Carcinoma Cell Proliferation, Migration, and Invasion Targeting DNMT3B.miR-129-2-3p 通过靶向 DNMT3B 抑制食管癌细胞增殖、迁移和侵袭
Curr Mol Pharmacol. 2023;16(1):116-123. doi: 10.2174/1874467215666220308122716.
9
MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3).微小 RNA miR-27b-3p 通过抑制 A20（TNF-α 诱导蛋白 3）来调节小胶质细胞炎症反应和细胞凋亡。
Bioengineered. 2021 Dec;12(2):9902-9913. doi: 10.1080/21655979.2021.1969195.
10
miR-221-3p regulates hepatocellular carcinoma cell proliferation, migration and invasion via targeting LIFR.miR-221-3p 通过靶向 LIFR 调节肝癌细胞增殖、迁移和侵袭。
Ann Hepatol. 2022 Jan;27 Suppl 1:100567. doi: 10.1016/j.aohep.2021.100567. Epub 2021 Oct 23.
Zotero 插件