与戊型肝炎病毒慢性感染相关的关键候选物的鉴定
Identification of key candidates associated with chronic hepatitis E viral infection.
作者信息
Shafat Zoya, Farooqui Anam, Tamkeen Naaila, Khan Nazim, Islam Asimul, Parveen Shama
机构信息
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
出版信息
Bioinformation. 2025 Jan 31;21(1):66-77. doi: 10.6026/973206300210066. eCollection 2025.
An in-depth understanding of chronic hepatitis E viral infection is of interest as the underlying molecular mechanisms remain unexplored. An analysis of mRNA expression profile revealed a total of 69, 157 and 411 Differentially Expressed Genes (DEG) for mild, moderate and severe hepatitis E viral infection, respectively. We found 8 up-regulated genes BATF2, OASL, IFI44L, IFIT3, RSAD2, IFIT1, RASGRP3 and IFI27 having association with persistent hepatitis E viral infection. Of these genes, 6 (OASL, IFI27, IFIT1, IFIT3, RSAD2 and IFI44L) were in protein-protein interaction network and at each stage of infection. Thus, this data provides insights into key genes and linked pathways which could be targeted to offer better interventions for chronic hepatitis E viral infection.
由于慢性戊型肝炎病毒感染的潜在分子机制仍未得到探索，因此对其进行深入了解具有重要意义。对mRNA表达谱的分析显示，轻度、中度和重度戊型肝炎病毒感染分别共有69个、157个和411个差异表达基因（DEG）。我们发现8个上调基因BATF2、OASL、IFI44L、IFIT3、RSAD2、IFIT1、RASGRP3和IFI27与持续性戊型肝炎病毒感染有关。在这些基因中，有6个（OASL、IFI27、IFIT1、IFIT3、RSAD2和IFI44L）处于蛋白质-蛋白质相互作用网络中，且在感染的各个阶段都存在。因此，这些数据为关键基因和相关途径提供了见解，可针对这些靶点为慢性戊型肝炎病毒感染提供更好的干预措施。
Zotero 插件