Yang Xiaowen, Lin Xiaotong, Zhou Zhenglin, Lin Bokun, Liu Xin
Dongguan Key Laboratory of Public Health Laboratory Science, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.
Biotechnol Lett. 2025 May 5;47(3):50. doi: 10.1007/s10529-025-03589-1.
Heavy metal pollution is a global issue that poses significant risks to ecosystems and human health. Microorganisms offer a promising bioremediation approach due to their ability to mitigate metal-induced metabolic damage in an eco-friendly, efficient, and cost-effective manner. Among them, Gram-positive Bacillus species exhibit a high heavy metal adsorption capacity and secrete metabolites with diverse functional properties. Under heavy metal stress, these metabolites play a crucial role in alleviating metal-induced damage. However, the application of Bacillus metabolites in heavy metal remediation faces challenges, including prolonged treatment durations, the necessity for stable environmental conditions, and specific nutrient requirements.This review summarizes recent research on the effects of heavy metal exposure on the metabolic pathways and metabolites of Bacillus spp., elucidates their role in influencing metal bioavailability and chemical transformations, and explores innovative strategies to enhance the stability of Bacillus-mediated heavy metal remediation. The review aims to provide valuable insights for optimizing bioremediation strategies, facilitating the selection of efficient degrading strains, and advancing the sustainable management of heavy metal contamination.
重金属污染是一个全球性问题，对生态系统和人类健康构成重大风险。微生物因其能够以生态友好、高效且经济有效的方式减轻金属诱导的代谢损伤，提供了一种很有前景的生物修复方法。其中，革兰氏阳性芽孢杆菌属物种具有较高的重金属吸附能力，并分泌具有多种功能特性的代谢产物。在重金属胁迫下，这些代谢产物在减轻金属诱导的损伤方面发挥着关键作用。然而，芽孢杆菌属代谢产物在重金属修复中的应用面临挑战，包括处理时间长、需要稳定的环境条件以及特定的营养需求。本综述总结了近期关于重金属暴露对芽孢杆菌属物种代谢途径和代谢产物影响的研究，阐明了它们在影响金属生物有效性和化学转化中的作用，并探索了增强芽孢杆菌介导的重金属修复稳定性的创新策略。该综述旨在为优化生物修复策略、促进高效降解菌株的选择以及推进重金属污染的可持续管理提供有价值的见解。
