Wilson J A, Murray T S
J R Coll Gen Pract. 1985 Jun;35(275):276-8.
In a general practice population of 57 000, 32 patients suffering from Parkinson's disease were identified from repeat prescription indexes and direct questioning of all members of the primary health care team. Of these patients 26 were receiving an L-dopa preparation and 10 an anticholinergic drug. The only newer drug found to be in use was bromocriptine and three patients were receiving this treatment.Of the 26 patients receiving an L-dopa preparation one received L-dopa alone, six L-dopa with benserazide (Madopar, Roche) and 19 L-dopa with carbidopa (Sinemet, Merck, Sharp and Dohme). The patients treated with Sinemet were receiving inadequate doses of carbidopa - three quarters received less than 75 mg per day which was in part a reflection of the low doses of L-dopa the patients received, the average dose being 468 mg per day. The L-dopa preparations were given in adequately spaced doses.The general practitioner made the diagnosis in 20 of the 32 cases and was in control of the drug therapy in 15 cases, however 25 cases were referred for specialist advice.
在一个57000人的普通医疗人群中，通过重复处方索引以及对基层医疗团队所有成员的直接询问，识别出32名帕金森病患者。这些患者中，26人正在接受左旋多巴制剂治疗，10人正在接受抗胆碱能药物治疗。发现唯一正在使用的新药是溴隐亭，有3名患者正在接受这种治疗。在接受左旋多巴制剂治疗的26名患者中，1人仅接受左旋多巴治疗，6人接受左旋多巴与苄丝肼（美多芭，罗氏公司）联合治疗，19人接受左旋多巴与卡比多巴（息宁，默克公司）联合治疗。接受息宁治疗的患者所接受的卡比多巴剂量不足——四分之三的患者每天接受的剂量低于75毫克，这在一定程度上反映了患者接受的左旋多巴剂量较低，平均剂量为每天468毫克。左旋多巴制剂的给药剂量间隔适当。32例病例中有20例由全科医生做出诊断，15例由全科医生控制药物治疗，然而有25例被转诊以寻求专科建议。
