Hayek J
Schweiz Med Wochenschr. 1977 Apr 9;107(14):474-9.
Forty patients have been treated with Sinemet (L-carbidopa/L-dopa) for a period of up to two years. The results are in agreement with those in the literature. In two-thirds of cases a good to very good improvement was obtained. The principal side effects were dyskinesia, hypotonia, and gastrointestinal and psychotic symptoms, though they seldom necessitated treatment interruption. L-carbidopa/L-dopa affords a real alternative therapy in the modern treatment of Parkinson's disease with L-dopa and a decarboxylase inhibitor. Generally the dosage range was up to a maximum of one tablet three times daily. Sinemet tablets are simple and convenient to handle for both doctor and patient. Dosage titration to therapeutic efficacy can be achieved in one week to ten days without complications, though we recommended a slower titration based on individual patient reaction and requirements.
40名患者接受了信尼麦（左旋卡比多巴/左旋多巴）治疗，疗程长达两年。结果与文献报道一致。三分之二的病例获得了良好至非常好的改善。主要副作用为运动障碍、肌张力减退、胃肠道和精神症状，不过很少需要中断治疗。左旋卡比多巴/左旋多巴为现代帕金森病治疗中使用左旋多巴和脱羧酶抑制剂提供了一种切实可行的替代疗法。一般剂量范围为每日最多三片，分三次服用。信尼麦片剂对医生和患者来说使用简单方便。一周至十天内即可完成剂量滴定以达到治疗效果，且无并发症，不过我们建议根据患者个体反应和需求进行更缓慢的滴定。
