Guo Huihui, Song Rui
Health Management Center, Yulin Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Yulin City, Shaanxi, China.
Department of Endocrinology, Yulin Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Yulin City, Shaanxi, China.
Medicine (Baltimore). 2025 May 2;104(18):e42377. doi: 10.1097/MD.0000000000042377.
The elevated level of homocysteine (Hcy) is considered to be a risk factor for cardiovascular diseases and many other diseases, and cardiovascular diseases occurs more frequently in men. The purpose of our study was to evaluate the factors associated with hyperhomocysteinemia (Hhcy) in relatively healthy adult males in northern Shaanxi. This is a cross-sectional study involving male participants who underwent health examinations at the Health Management Center of Yulin Hospital, the first affiliated Hospital of Xi'an Jiaotong University in 2023. Hhcy was defined as plasma homocysteine ≥15 mmol/L. The related factors of Hhcy were analyzed by univariate and multivariate logistic regression. A total of 728 adult males were enrolled, with a median age of 36 years, of whom 274 (37.6%) had Hhcy. Multivariate logistic regression analysis showed that height, methylenetetrahydrofolate reductase TT genotype (hereinafter referred to as TT genotype), uric acid, thyroid stimulating hormone and alpha fetoprotein were significantly associated with Hhcy. In this cross-sectional study, height, TT genotype, uric acid, thyroid stimulating hormone and alpha fetoprotein were significantly associated with Hhcy in relatively healthy adult males in northern Shaanxi.
同型半胱氨酸（Hcy）水平升高被认为是心血管疾病和许多其他疾病的危险因素，且心血管疾病在男性中更为常见。我们研究的目的是评估陕北相对健康成年男性中与高同型半胱氨酸血症（Hhcy）相关的因素。这是一项横断面研究，研究对象为2023年在西安交通大学第一附属医院榆林医院健康管理中心接受健康检查的男性参与者。Hhcy定义为血浆同型半胱氨酸≥15 mmol/L。采用单因素和多因素logistic回归分析Hhcy的相关因素。共纳入728名成年男性，中位年龄为36岁，其中274人（37.6%）患有Hhcy。多因素logistic回归分析显示，身高、亚甲基四氢叶酸还原酶TT基因型（以下简称TT基因型）、尿酸、促甲状腺激素和甲胎蛋白与Hhcy显著相关。在这项横断面研究中，身高、TT基因型、尿酸、促甲状腺激素和甲胎蛋白与陕北相对健康成年男性的Hhcy显著相关。
