Yang Zhou, Cao Wenjie, Qin Haofang, Lu Xiaojie, Wang Yanliang, Liu Dong
Department of Ophthalmology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China.
Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Medicine (Baltimore). 2025 May 2;104(18):e42348. doi: 10.1097/MD.0000000000042348.
The present study aimed to explore the association between weight-adjusted waist index (WWI) levels, a newly proposed indicator for assessing obesity, and the risk of age-related macular degeneration (AMD). A cross-sectional analysis of 20,497 participants was conducted using the National Health and Nutrition Examination Survey (NHANES) 2005-2008 dataset. Trend tests, multivariable logistic regression, and smoothing curve fitting were performed to examine the association between WWI and the risk of AMD. In addition, subgroup analysis and interaction tests were used to test this association in different groups. A total of 5476 participants were included in the study, of whom 420 (7.7%) had AMD. The risk of age-related macular degeneration increased with increasing WWI in all models. In the fully adjusted model, a 55% increase in the prevalence of AMD was observed in the highest tertile (tertile 3: >11.52) of WWI (OR 1.55, 95% CI 1.09, 2.21) compared to the lowest tertile (tertile 1: <10.85). The interaction tests revealed that age, chronic kidney disease, and cardiovascular disease had significant interactions with WWI on AMD risk (P for interaction < .05). This study revealed that higher WWI levels were associated with increased risk of AMD, suggesting that managing obesity according to WWI may reduce AMD risk. However, additional research is warranted to corroborate our results.
本研究旨在探讨体重调整腰围指数（WWI）水平（一种新提出的评估肥胖的指标）与年龄相关性黄斑变性（AMD）风险之间的关联。使用2005 - 2008年美国国家健康与营养检查调查（NHANES）数据集对20497名参与者进行了横断面分析。进行趋势检验、多变量逻辑回归和平滑曲线拟合以检验WWI与AMD风险之间的关联。此外，采用亚组分析和交互作用检验来在不同组中检验这种关联。共有5476名参与者纳入研究，其中420名（7.7%）患有AMD。在所有模型中，年龄相关性黄斑变性的风险随WWI升高而增加。在完全调整模型中，与最低三分位数（三分位数1：<10.85）相比，WWI最高三分位数（三分位数3：>11.52）的参与者中AMD患病率增加了55%（比值比1.55，95%置信区间1.09，2.21）。交互作用检验显示，年龄、慢性肾脏病和心血管疾病与WWI在AMD风险上存在显著交互作用（交互作用P<0.05）。本研究表明，较高的WWI水平与AMD风险增加相关，这表明根据WWI管理肥胖可能会降低AMD风险。然而，需要进一步的研究来证实我们的结果。
