Isodon rubescens has been used as an herbal medicine in China for a long time. The significant value of development and utilization is affirmative. Bibliometrics is used as an approach to sort out, analyze, and visualize relevant literature in a particular field. So, it can intuitively express the research trends, hot directions, significant achievements, core journals, and outstanding authors in the field. But there is no bibliometrics analysis of I rubescens. The relevant dataset was retrieved and exported from the Web of Science database, and the results were obtained and visualized using the R Programming Language, CiteSpace, and VOSviewer, with the creation of time zone maps also using Scimago Graphica and Gephi. There were 506 valid data retrieved and 465 analyzed data selected. The country with the most significant number of publications is China, the institution with the largest annual publication volume is China Pharmaceutical University, the publication with the most relevant literature is the International Journal of Oncology, and the author with the most publications is Zhou. The keyword with the greatest intensity is "matastasis," which is also an emerging keyword. The role of I rubescens has been continuously diversifying. It has been proven to play a role in treating major diseases such as multiple cancers, leukemia, liver and kidney function impairment, and cardiovascular and cerebrovascular diseases. This study will highlight the main research direction in this field, namely the use of I rubescens for the treatment of cancer.