Xue Junqiang, Yin Ping, He Jianping, Wei Hui, Geng Cuijie, Luo Yuxian
Department of Vascular Surgery, Shijiazhuang People's Hospital, Shijiazhuang, Hebei, China.
Department of Laboratory Medicine, Shijiazhuang Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei, China.
Medicine (Baltimore). 2025 May 2;104(18):e41982. doi: 10.1097/MD.0000000000041982.
This study aims to explore the advantages and limitations of AngioJet mechanical thrombectomy combined with catheter-directed thrombolysis (CDT), providing reference for clinical treatment. Electronic medical records of 192 patients with lower extremity deep vein thrombosis (LEDVT) who visited our hospital from January 2022 to December 2023 were included. Patients were matched using propensity scores based on their thrombosis treatment method: the experimental group received AngioJet thrombectomy combined with CDT, while the control group received CDT alone. Outcomes were compared post-matching, including treatment effectiveness, coagulation, valve condition, complications, and quality of life. This study evaluated the efficacy of AngioJet mechanical thrombectomy (PMT) combined with CDT in treating acute LEDVT. The combined approach led to better vessel patency, greater limb swelling reduction, improved coagulation function, and less venous valve damage compared to CDT alone. Additionally, it significantly reduced the occurrence and severity of post-thrombotic syndrome and enhanced patient quality of life, particularly in physical pain and physiological function. The combination of PMT and CDT demonstrated superior efficacy in restoring venous function, alleviating symptoms, and reducing long-term complications. These findings support the clinical advantage of combined therapy in improving patient outcomes while maintaining a favorable safety profile.
本研究旨在探讨AngioJet机械血栓切除术联合导管定向溶栓（CDT）的优势与局限性，为临床治疗提供参考。纳入了2022年1月至2023年12月期间来我院就诊的192例下肢深静脉血栓形成（LEDVT）患者的电子病历。根据患者的血栓治疗方法，采用倾向评分进行匹配：实验组接受AngioJet血栓切除术联合CDT，而对照组仅接受CDT。匹配后比较各项结果，包括治疗效果、凝血功能、瓣膜状况、并发症及生活质量。本研究评估了AngioJet机械血栓切除术（PMT）联合CDT治疗急性LEDVT的疗效。与单纯CDT相比，联合治疗方法导致更好的血管通畅性、更大程度的肢体肿胀减轻、改善的凝血功能以及更少的静脉瓣膜损伤。此外，它显著降低了血栓形成后综合征的发生率和严重程度，并提高了患者的生活质量，尤其是在身体疼痛和生理功能方面。PMT与CDT联合在恢复静脉功能、缓解症状及减少长期并发症方面显示出卓越的疗效。这些发现支持了联合治疗在改善患者预后同时保持良好安全性方面的临床优势。
