Al-Jawad Mohammad, Akil Mohamed Nizar, Nabhan Mohammad Hassan, Abdulaziz Danah, Kanaa Leen, Bek Nazima Ali, Niazi Ammar
Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic.
Medicine (Baltimore). 2025 May 2;104(18):e42339. doi: 10.1097/MD.0000000000042339.
Encapsulated papillary carcinoma (EPC) is a rare subtype of breast cancer characterized by a favorable prognosis; however, its management can be complex, especially when associated with ductal carcinoma in situ (CIS) or invasive components. This study aimed to highlight the clinical presentation, diagnostic approach, and treatment outcomes of EPC to improve understanding and management strategies for this unique breast cancer subtype.
We present 2 cases of elderly women who presented with breast lumps, prompting concerns regarding the nature of the lesions and the need for effective management strategies.
Case 1 involved a 67-year-old woman diagnosed with EPC within an inflammatory cyst wall, while case 2 was an 85-year-old woman with EPC and low-grade papillary CIS. Both diagnoses were confirmed through imaging and histopathological examination.
Both patients underwent complete surgical resection of the tumors. Case 1 required no additional therapy postsurgery, while case 2 was monitored regularly without further treatment.
Both patients remained healthy following their respective interventions, with no evidence of recurrence noted during follow-up.
Early diagnosis and appropriate surgical intervention are critical in managing EPC. Regular monitoring is essential, particularly for cases with associated ductal CIS or invasive components, to ensure favorable outcomes.
包膜性乳头状癌(EPC)是一种罕见的乳腺癌亚型,预后良好;然而,其治疗可能较为复杂,尤其是与导管原位癌(CIS)或浸润性成分相关时。本研究旨在强调EPC的临床表现、诊断方法和治疗结果,以增进对这种独特乳腺癌亚型的理解和管理策略。
我们报告2例老年女性患者,她们因乳腺肿块就诊,引发了对病变性质以及有效管理策略需求的关注。
病例1为一名67岁女性,在炎性囊肿壁内诊断为EPC;病例2是一名85岁女性,患有EPC和低级别乳头状CIS。两个诊断均通过影像学和组织病理学检查得以证实。
两名患者均接受了肿瘤的完整手术切除。病例1术后无需额外治疗,病例2则定期监测,未进行进一步治疗。
两名患者在各自接受干预后均保持健康,随访期间未发现复发迹象。
早期诊断和适当的手术干预对于EPC的治疗至关重要。定期监测必不可少,尤其是对于伴有导管CIS或浸润性成分的病例,以确保良好的治疗效果。