Leng Junsheng, Jin Zhaoheng, Deng Jianhua, Ji Zhigang
Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences (CAMS), Beijing, China.
Medicine (Baltimore). 2025 May 2;104(18):e42220. doi: 10.1097/MD.0000000000042220.
Psoriasis has been suggested to be associated with urolithiasis. However, the existing literature is based on observational studies, which provide limited evidence for the causal relationship between these two conditions. This research aims to evaluate the causal association between psoriasis vulgaris and urolithiasis using 2-sample Mendelian Randomization (MR) analysis. Exposures and outcomes were sourced from genome-wide association study data. The psoriasis vulgaris dataset included 5072 patients and 4,78,102 controls. The urolithiasis dataset included 5347 patients and 2,13,445 controls. We used the inverse-variance weighted (IVW) method as our primary analytical strategy, augmented by MR-Egger regression and the weighted median method. Cochran Q test, MR-Egger regression, leave-one-out analysis and Steiger filtering were also conducted to evaluated the stability and credibility of the results. The IVW analysis showed a significant association between psoriasis vulgaris and urolithiasis (odds ratio [OR] = 1.073, 95% confidence interval [CI] = 1.017-1.131, P = .010). The results of weighted median analysis (OR = 1.071, 95% CI = 1.013-1.133, P = .017) and MR-Egger regression (OR = 1.072, 95% CI = 0.992-1.158, P = .12) indicated a consistent directional causality with the IVW analysis. There was no significant horizontal pleiotropy or heterogeneity in the analysis. Steiger filtering further confirmed the accuracy of the directional causality. In conclusion, this MR study supports a causal association between psoriasis vulgaris and urolithiasis.
有研究表明银屑病与尿石症有关。然而，现有文献基于观察性研究，为这两种疾病之间的因果关系提供的证据有限。本研究旨在使用两样本孟德尔随机化（MR）分析评估寻常型银屑病与尿石症之间的因果关联。暴露因素和结局数据均来源于全基因组关联研究数据。寻常型银屑病数据集包括5072例患者和478102例对照。尿石症数据集包括5347例患者和213445例对照。我们采用逆方差加权（IVW）方法作为主要分析策略，并辅以MR-Egger回归和加权中位数法。还进行了Cochran Q检验、MR-Egger回归、留一法分析和Steiger过滤，以评估结果的稳定性和可信度。IVW分析显示寻常型银屑病与尿石症之间存在显著关联（优势比[OR]=1.073，95%置信区间[CI]=1.017-1.131，P=.010）。加权中位数分析结果（OR=1.071，95%CI=1.013-1.133，P=.017）和MR-Egger回归结果（OR=1.072，95%CI=0.992-1.158，P=.12）表明与IVW分析存在一致的方向性因果关系。分析中未发现显著的水平多效性或异质性。Steiger过滤进一步证实了方向性因果关系的准确性。综上所述，本MR研究支持寻常型银屑病与尿石症之间存在因果关联。
