Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Skin Res Technol. 2024 Mar;30(3):e13629. doi: 10.1111/srt.13629.
Although many studies have investigated the association between psoriasis and chronic obstructive pulmonary disease (COPD), the causal relationship between psoriasis and COPD is still unknown.
We employed bidirectional Mendelian randomization to investigate the causal relationship between psoriasis and COPD. Genetic instruments for exposure were selected from two distinct genome-wide association study databases. Single nucleotide polymorphisms associated with exposures at the genome-wide significance level (p < 5 × 10^ ) and exhibiting low linkage disequilibrium (r < 0.001) were chosen as instrumental variables. Causality was assessed using multiple MR methods, including Inverse-Variance Weighted (IVW), MR-Egger, Weighted Median, Simple Mode, and Weighted Mode. A significance level of p < 0.05 was considered statistically significant. Heterogeneity was examined using Cochran's Q test, and MR-Egger regression was employed to detect pleiotropy. The robustness and reliability of the results were further evaluated through leave-one-out analysis.
We found a positive causal association between psoriasis and COPD [IVW: odds ratio (OR): 1.0006; p = 0.0056]. Heterogeneity and pleiotropy have not been discovered, so the results of the study are reliable. In the reverse analysis, no causal association between CPOD and psoriasis was found.
Our findings revealed that psoriasis was associated with an elevated risk of COPD. However, no causal association between COPD and psoriasis was identified in our study.
尽管许多研究已经调查了银屑病和慢性阻塞性肺疾病（COPD）之间的关联，但银屑病和 COPD 之间的因果关系尚不清楚。
我们采用双向孟德尔随机化来研究银屑病和 COPD 之间的因果关系。暴露的遗传工具是从两个不同的全基因组关联研究数据库中选择的。选择与全基因组关联研究显著水平（p<5×10^）相关且显示低连锁不平衡（r<0.001）的单核苷酸多态性作为工具变量。使用多种 MR 方法评估因果关系，包括逆方差加权（IVW）、MR-Egger、加权中位数、简单模式和加权模式。p<0.05 被认为具有统计学意义。使用 Cochran's Q 检验检查异质性，并用 MR-Egger 回归检测偏倚。通过逐一剔除分析进一步评估结果的稳健性和可靠性。
我们发现银屑病和 COPD 之间存在正因果关联[IVW：比值比（OR）：1.0006；p=0.0056]。未发现异质性和偏倚，因此研究结果可靠。在反向分析中，未发现 COPD 和银屑病之间存在因果关系。
我们的研究结果表明，银屑病与 COPD 风险增加相关。然而，我们的研究未发现 COPD 和银屑病之间存在因果关系。
