Hadjipetrou-Kourounakis L, Manikou H, Tsougranis A
J Clin Lab Immunol. 1985 Mar;16(3):149-53.
The ConA and PWM responses of blood lymphocytes from lung cancer patients (LC) was found to be diminished in comparison to normal. LC sera inhibited the blastogenic response of normal human and rat lymphocytes, suggesting that there is a common inhibitory mechanism. Addition of normal serum to lung cancer blood lymphocytes allows a restoration of the diminished proliferative responses to normal or near normal levels, except to high ConA concentrations. Possible explanations for this finding are discussed.
肺癌患者（LC）血液淋巴细胞的刀豆球蛋白A（ConA）和美洲商陆有丝分裂原（PWM）反应与正常人相比有所减弱。肺癌患者血清抑制正常人及大鼠淋巴细胞的母细胞化反应，提示存在共同的抑制机制。向肺癌患者血液淋巴细胞中加入正常血清可使减弱的增殖反应恢复至正常或接近正常水平，但对高浓度ConA除外。文中讨论了这一发现的可能解释。
