Liu Yu-Hua, Chen Chiao-Yun, Muggleton Neil G
Department of Criminology, National Chung Cheng University, Chiayi, Taiwan.
Cognitive Intelligence and Precision Healthcare Center, National Central University, Taoyuan, Taiwan.
Addict Biol. 2025 May;30(5):e70041. doi: 10.1111/adb.70041.
In Taiwan, amphetamines are the main drug of abuse. While drug abuse is often related to individual risky decision-making, how this relates to underlying neural mechanisms in amphetamine abusers remains unclear. The current study was carried out to help better understand this. A Balloon Analogue Risk Task (BART) was used to examine individual risky decision-making in conjunction with event-related potential (ERP) recording and presentation of questionnaires relating to behavioural control. Compared with healthy controls, amphetamine users had a lower score on the Behavioural Inhibition System (BIS) scale and showed reduced amplitudes in feedback-related negativity (FRN) and error-related negativity (ERN) ERP components following negative feedback on the task. Amphetamine users were less sensitive to punitive or aversive stimuli. This reduced sensitivity might lead to a higher tendency for risky decision-making, with them less able to learn from mistakes and thus repeatedly engage in risky behaviours.
在台湾，安非他命是主要的滥用药物。虽然药物滥用通常与个人的冒险决策有关，但这与安非他命滥用者潜在的神经机制之间的关系仍不清楚。开展本研究是为了更好地理解这一点。使用气球模拟风险任务（BART）结合事件相关电位（ERP）记录以及与行为控制相关的问卷来检查个人的冒险决策。与健康对照组相比，安非他命使用者在行为抑制系统（BIS）量表上得分较低，并且在任务中得到负面反馈后，反馈相关负波（FRN）和错误相关负波（ERN）这两个ERP成分的波幅降低。安非他命使用者对惩罚性或厌恶刺激性刺激不太敏感。这种降低的敏感性可能导致更高的冒险决策倾向，他们从错误中学习的能力较差，因此会反复从事冒险行为。
