Zhong Na, Chen Tianzhen, Zhu Youwei, Su Hang, Ruan Xiaolu, Li Xiaotong, Tan Haoye, Jiang Haifeng, Du Jiang, Zhao Min
Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
Front Psychiatry. 2020 Apr 21;11:320. doi: 10.3389/fpsyt.2020.00320. eCollection 2020.
Methamphetamine (MA) chronic users show risky decision-making deficits. However, the neural mechanisms underlying these deficits remain unclear. A case-control study was conducted to understand how MA users and healthy controls differ in electrophysiological responses associated with series decision-making. Electroencephalography of 31 MA users and 27 healthy controls was recorded when they performed the Balloon Analogue Risk Task involving risky decision-making with uncertain gain or loss. Feedback-related negativity (FRN) was measured and their association with their risky decision-making and impulsivity were examined. Compared to healthy controls, MA users showed smaller peak FRN amplitudes in fronto-central electrodes (F =4.559, p=0.037), and the attenuated peak FRN amplitudes correlated with more risk-taking behavior (r=0.48, p=0.012). Besides, MA users exhibited later FRN (F = 7.561, p=0.008) and earlier P300 (F = 3.582, p = 0.041) compared to healthy controls in fronto-central electrodes, which were correlated with higher score of impulsivity. These findings provided further evidence that MA users showed insensitivity to negative feedback in risky decision-making. FRN might be a promising biomarker of dependence.
甲基苯丙胺（MA）长期使用者表现出风险决策缺陷。然而，这些缺陷背后的神经机制仍不清楚。进行了一项病例对照研究，以了解MA使用者和健康对照者在与系列决策相关的电生理反应方面有何不同。当31名MA使用者和27名健康对照者执行涉及不确定收益或损失的风险决策的气球模拟风险任务时，记录了他们的脑电图。测量了反馈相关负波（FRN），并检查了其与风险决策和冲动性的关联。与健康对照者相比，MA使用者在额中央电极上的FRN峰值幅度较小（F = 4.559，p = 0.037），且FRN峰值幅度减弱与更多的冒险行为相关（r = 0.48，p = 0.012）。此外，与健康对照者相比，MA使用者在额中央电极上的FRN出现得更晚（F = 7.561，p = 0.008），P300出现得更早（F = 3.582，p = 0.041），这与更高的冲动性得分相关。这些发现进一步证明，MA使用者在风险决策中对负面反馈不敏感。FRN可能是一种有前景的依赖生物标志物。
