Langley A E, Pilcher G D
J Toxicol Environ Health. 1985;15(3-4):485-91. doi: 10.1080/15287398509530675.
A single ip injection of perfluoro-n-decanoic acid (PFDA) to male Wistar rats resulted in an initially rapid, then gradual decrease in food consumption and a parallel loss of body weight. Body temperatures and resting heart rates were significantly depressed by PFDA treatment. As early as 12 h following a single dose of PFDA, serum thyroxine (T4) levels were significantly reduced and remained depressed throughout the 8 day study. Serum triiodothyronine (T3) was reduced by 35% 12 h following PFDA treatment and remained at that level throughout the study. These preliminary data suggest that an action on the thyroid axis may be an early primary response to PFDA and that some of the observed subsequent effects may in part be secondary to the change in thyroid hormone levels.
对雄性Wistar大鼠单次腹腔注射全氟癸酸（PFDA）后，食物摄入量最初迅速减少，随后逐渐下降，体重也相应减轻。PFDA处理显著降低了体温和静息心率。在单次注射PFDA后12小时，血清甲状腺素（T4）水平就显著降低，并在整个8天的研究中持续处于较低水平。PFDA处理后12小时，血清三碘甲状腺原氨酸（T3）降低了35%，并在整个研究过程中维持在该水平。这些初步数据表明，对甲状腺轴的作用可能是对PFDA的早期主要反应，并且随后观察到的一些影响可能部分继发于甲状腺激素水平的变化。
