Danis Esra Gulsum, Mogulkoc Rasim, Baltaci Abdulkerim Kasim
Department of Physiology, Medical School, Selcuk University, Konya, Turkey.
CNS Neurol Disord Drug Targets. 2025 Apr 30. doi: 10.2174/0118715273374176250414051135.
Brain ischemia-reperfusion injury (CIRI) refers to brain ischemia that leads to cellular dysfunction and cell death after a certain period, and ischemic damage is rescued by providing blood supply and reperfusion. And then, reperfusion includes components such as ion imbalance, mitochondrial dysfunction, oxidative stress, neuroinflammation, Ca2+ overload, and apoptosis, which do not cause tissue damage. Autophagy also occurs in CIRI due to oxygen deficiency, and autophagy has been shown to protect cells from ischemic injury. Flavonoids are a class of essential and diversified secondary plant metabolites found in different concentrations in leaves, flowers, roots, and fruits. Various studies have shown that flavonoids have healing qualifications such as anti-inflammatory, antimutagenic, anticarcinogenic, and antimicrobial. We aim to determine how flavonoids may affect signaling pathways and kinases in rats with CIRI. The results show that the activity of JAK2/STAT3, NF-κB, RhoA/ROCK, JNK-p38, and cAMKII signaling pathways increases under CIRI, and the PI3K/Akt/mTOR signaling pathway is suppressed. Studies using various flavonoids (kaempferol, chrysin, naringin, naringenin, quercetin, wogonin) have shown a neuroprotective effect by reversing the situation in signaling pathways during CIRI damage.
脑缺血再灌注损伤（CIRI）是指脑缺血一段时间后导致细胞功能障碍和细胞死亡，而通过恢复血液供应和再灌注可挽救缺血损伤。然后，再灌注包括离子失衡、线粒体功能障碍、氧化应激、神经炎症、Ca2+超载和细胞凋亡等成分，这些成分不会导致组织损伤。由于缺氧，自噬也会在CIRI中发生，并且自噬已被证明可保护细胞免受缺血损伤。黄酮类化合物是一类重要且多样的次生植物代谢产物，在叶片、花朵、根和果实中以不同浓度存在。各种研究表明，黄酮类化合物具有抗炎、抗诱变、抗癌和抗菌等治疗特性。我们旨在确定黄酮类化合物如何影响CIRI大鼠的信号通路和激酶。结果表明，在CIRI条件下，JAK2/STAT3、NF-κB、RhoA/ROCK、JNK-p38和cAMKII信号通路的活性增加，而PI3K/Akt/mTOR信号通路受到抑制。使用各种黄酮类化合物（山奈酚、白杨素、柚皮苷、柚皮素、槲皮素、汉黄芩素）的研究表明，通过逆转CIRI损伤期间信号通路的情况可产生神经保护作用。
