Atalay Sabri, Mert Kamil, Caglayan Derya, Sonmez Ufuk, Akbulut Ilkay
Department of Infectious Diseases and Clinical Microbiology, Izmir Tepecik Education and Research Hospital, University of HealthSciences, Izmir, Turkey.
Malazgirt Public Hospital, Mus, Turkey.
HIV Med. 2025 Jul;26(7):1150-1156. doi: 10.1111/hiv.70042. Epub 2025 May 6.
Treatment adherence is extremely important for virological suppression and a good clinical outcome in HIV. People with good adherence to treatment are less likely to experience treatment failure and have a better clinical course of the infection. In this study, we aimed to elucidate the factors affecting treatment adherence in people with HIV in a single centre from Turkey.
The study was conducted at Tepecik Training and Research Hospital between September 2022 and December 2022. People with HIV over the age of 18 years who had been on ART for at least 6 months were included. Researchers designed a questionnaire by reviewing the literature to include factors that may affect treatment adherence.
A total of 306 people participated in the study (non-response rate: 30%), of which 86% were male. Among the individual factors, feeling depressed (19.5%), treatment fatigue (18.5%), and anxiety about not being able to have a healthy child (18.2%) were prominent. Major HIV/AIDS-related factors were the presence of AIDS-related opportunistic infection/cancer/comorbidity (20.9%) and lack of cure with current treatment (20.5%). Concern about side effects (14.6%) and drug-drug interaction (13.6%) were the most frequently mentioned ART-related factors. Main healthcare facility-related barriers for adherence were insufficient counselling (15.2%) and inability to reach the HIV physician (15.1%). Only a few patients stated factors related to the health system.
In our study, the most significant factors affecting treatment adherence appeared to be individual and HIV/AIDS-related. It is important to be aware of these factors and to spend time on tailored counselling during initial diagnosis and follow-up visits.
治疗依从性对于艾滋病毒感染者的病毒学抑制和良好的临床结局极为重要。坚持治疗的人发生治疗失败的可能性较小，并且感染的临床病程更好。在本研究中，我们旨在阐明土耳其一个单一中心内影响艾滋病毒感染者治疗依从性的因素。
该研究于2022年9月至2022年12月在特佩奇克培训与研究医院进行。纳入了年龄在18岁以上且接受抗逆转录病毒治疗（ART）至少6个月的艾滋病毒感染者。研究人员通过查阅文献设计了一份问卷，以纳入可能影响治疗依从性的因素。
共有306人参与了该研究（无应答率：30%），其中86%为男性。在个体因素中，感到抑郁（19.5%）、治疗疲劳（18.5%）以及对无法生育健康孩子的焦虑（18.2%）较为突出。与艾滋病毒/艾滋病相关的主要因素是存在艾滋病相关的机会性感染/癌症/合并症（20.9%）以及当前治疗无法治愈（20.5%）。对副作用的担忧（14.6%）和药物相互作用（13.6%）是最常提及的与抗逆转录病毒治疗相关的因素。依从性方面主要的医疗保健机构相关障碍是咨询不足（15.2%）和无法联系到艾滋病毒医生（15.1%）。只有少数患者提到了与卫生系统相关的因素。
在我们的研究中，影响治疗依从性的最显著因素似乎是个体因素和与艾滋病毒/艾滋病相关的因素。在初次诊断和随访期间了解这些因素并进行针对性咨询很重要。
