Vitulli Francesca, Tortora Domenico, Pacetti Mattia, Spacca Barbara, Agushi Rina, Tamburrini Gianpiero, Nobili Lino, Cognolato Erica, Genitori Lorenzo, Giordano Flavio, Piatelli Gianluca, Consales Alessandro
Neurosurgery Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Department of Neurosciences and Reproductive and Dental Sciences, Division of Neurosurgery, "Federico II" University of Naples, Naples, Italy.
Neurol Sci. 2025 May 6. doi: 10.1007/s10072-025-08213-8.
Magnetic Resonance-guided Laser interstitial Thermal Therapy (MR-gLiTT) has established itself as a minimally invasive neurosurgical approach for the treatment of various pediatric brain lesions, including tumors and epilepsy.
The work is likely to focus on evaluating the efficacy, safety and applicability of MR-gLiTT while investigating its potential to minimize surgical risks, shorten recovery time and improve patient outcomes.
This paper presents the results of a survey conducted in three leading italian pediatric hospitals to investigate the use of MR-gLiTT in pediatric patients with neurosurgical conditions. Data on patient demographics, primary diagnoses, MR-gLiTT parameters, perioperative complications and postoperative outcomes were collected and analysed.
A total of 29 pediatric patients were included in the analysis. The median age at diagnosis was 36 months, with a predominance of males (58.6%). The most common indications were hypothalamic hamartomas (41.4%) and focal cortical dysplasia (24.1%). Perioperative complications were transient in nature (17.2%), with focal muscle weakness being the most frequent, while only one patient experienced a permanent hypoadrenocorticism. The average hospital stay was 6.48 days, with a mean follow-up duration of 23.12 months.
The adoption of MR-gLiTT in pediatric neurosurgery offers a promising minimally invasive approach with favorable outcomes. The efficacy in treating various pediatric neurological conditions is evident, suggesting its potential to reduce surgical risks, shorten hospital stays, and improve patient quality of life. Further clinical trials and prospective studies are required to fully understand the advantages of MR-gLiTT in pediatric neurosurgery.
磁共振引导激光间质热疗（MR - gLiTT）已成为一种用于治疗各种小儿脑部病变（包括肿瘤和癫痫）的微创神经外科手术方法。
这项工作可能侧重于评估MR - gLiTT的疗效、安全性和适用性，同时研究其将手术风险降至最低、缩短恢复时间并改善患者预后的潜力。
本文介绍了在意大利三家领先的儿科医院进行的一项调查结果，以研究MR - gLiTT在患有神经外科疾病的儿科患者中的应用。收集并分析了患者人口统计学、主要诊断、MR - gLiTT参数、围手术期并发症和术后结果的数据。
共有29名儿科患者纳入分析。诊断时的中位年龄为36个月，男性占多数（58.6%）。最常见的适应症是下丘脑错构瘤（41.4%）和局灶性皮质发育不良（24.1%）。围手术期并发症本质上是短暂性的（17.2%），局灶性肌肉无力最为常见，而只有一名患者出现永久性肾上腺皮质功能减退。平均住院时间为6.48天，平均随访时间为23.12个月。
MR - gLiTT在小儿神经外科中的应用提供了一种前景广阔的微创方法，效果良好。在治疗各种小儿神经疾病方面的疗效明显，表明其有降低手术风险、缩短住院时间和改善患者生活质量的潜力。需要进一步的临床试验和前瞻性研究来充分了解MR - gLiTT在小儿神经外科中的优势。
