Priya S Shanmuga, Suseem S R
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
J Fluoresc. 2025 May 6. doi: 10.1007/s10895-025-04341-8.
This research presents a straightforward approach to synthesizing advanced nanomaterials derived from the herb Borreria Hispida, focusing on their use in environmental and biological applications. Utilizing a simple hydrothermal process, nitrogen-doped carbon dots were produced from Borreria Hispida and ortho-phenylenediamine. Various analytical techniques such as XRD, TEM, FTIR, CHNS, UV-Vis, and photoluminescence spectroscopy were employed to characterize the carbon dots. The synthesized nanomaterials displayed exceptional water solubility and robust UV light stability, coupled with a high quantum yield of 9%. With particle sizes ranging from 0.5 to 3.5 nm, the carbon dots demonstrated superior sensitivity and selectivity in detecting VO ions through a fluorometric sensing mechanism, achieving a detection limit as low as 0.25 µM. The sensing mechanism was based on a binding model where two nitrogen atoms from the carbon dots interact with a single VO ion in a 2:1 ratio. Additionally, cytotoxicity tests revealed that the N-CDs significantly inhibited the growth of MCF7 breast cancer cells, with cell viability reaching a maximum of 92%. This research highlights the versatility of N-CDs in both environmental monitoring and biomedical fields.
本研究提出了一种直接的方法来合成源自草药糙叶丰花草的先进纳米材料，重点关注其在环境和生物应用中的用途。利用简单的水热法，由糙叶丰花草和邻苯二胺制备出了氮掺杂碳点。采用了各种分析技术，如XRD、TEM、FTIR、CHNS、UV-Vis和光致发光光谱来表征碳点。合成的纳米材料表现出优异的水溶性和强大的紫外光稳定性，量子产率高达9%。碳点的粒径范围为0.5至3.5纳米，通过荧光传感机制在检测VO离子时表现出卓越的灵敏度和选择性，检测限低至0.25 μM。传感机制基于一种结合模型，其中碳点的两个氮原子与单个VO离子以2:1的比例相互作用。此外，细胞毒性测试表明，氮掺杂碳点显著抑制了MCF7乳腺癌细胞的生长，细胞活力最高达到92%。本研究突出了氮掺杂碳点在环境监测和生物医学领域的多功能性。
