Gallo Giovanna, Autore Camillo, Volterrani Maurizio, Barbato Emanuele, Volpe Massimo
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa 1035-1039, 00189, Rome, Italy.
Cardiology Unit, Sant'Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy.
High Blood Press Cardiovasc Prev. 2025 May;32(3):287-297. doi: 10.1007/s40292-025-00707-y. Epub 2025 May 6.
Heart failure (HF) is characterized by poor exercise tolerance and reduced ability to perform routine daily activities. Cardiac rehabilitation (CR), which includes exercise training, has shown a role in improving cardiac remodeling, functional capacity and HF outcomes as a consequence of its beneficial effects on neurohormonal dysfunction, endothelial function, vascular tone and peripheral oxygen extraction. Although a multiparametric evaluation, including physical examination, blood sampling, echocardiographic and cardiopulmonary exercise testing parameters, is routinely performed during CR programs, the use of cardiac biomarkers, in particular natriuretic peptides (NPs), is still poorly adopted and characterized. In this article we analyze the potential role of biomarkers in monitoring the success of rehabilitation programs and the potential implications of their use in clinical practice. Indeed, NPs measurements might represent an important tool to modulate the rehabilitative interventions with a favorable cost-effectiveness profile.
心力衰竭（HF）的特征是运动耐量差和进行日常活动的能力下降。心脏康复（CR）包括运动训练，由于其对神经激素功能障碍、内皮功能、血管张力和外周氧摄取具有有益作用，已显示出在改善心脏重塑、功能能力和心力衰竭结局方面的作用。尽管在心脏康复计划中通常会进行多参数评估，包括体格检查、血液采样、超声心动图和心肺运动测试参数，但心脏生物标志物，特别是利钠肽（NPs）的使用仍然很少且缺乏特征描述。在本文中，我们分析了生物标志物在监测康复计划成功方面的潜在作用及其在临床实践中使用的潜在影响。事实上，利钠肽测量可能是一种重要工具，可用于以良好的成本效益概况调整康复干预措施。
