Nguyen Kaycee, Chen Aaron, Mohammad K Shalabi Mojahed, C Lauck Kyle, Mehrmal Sino, Kelley Benjamin, N Tolkachjov Stanislav
J Drugs Dermatol. 2025 May 1;24(5):444-446. doi: 10.36849/JDD.8779.
Cylindromas are benign adnexal tumors often associated with conditions such as Brooke-Spiegler Syndrome and familial cylindromatosis. Cylindromas can undergo malignant transformation into cylindrocarcinoma. Although surgical excision is the conventional treatment method for cylindrocarcinoma, comparative studies of outcomes and recurrence rates between Mohs micrographic surgery (MMS) and surgical excision are limited.
This study's purpose is to analyze surgical outcomes of MMS and traditional surgical excision for cylindrocarcinoma based on published recurrence and metastasis data.
A systematic review was conducted utilizing PubMed and SCOPUS to identify articles addressing the treatment of cylindrocarcinoma through excision and/or MMS from inception to May 2024. The search terms included cylindrocarcinoma, malignant cylindroma, and cylindromatous carcinoma.
We identified 11 articles covering 12 patients and 18 procedures. 75% of MMS treatments (3/4) exhibited no recurrence, whereas only 42% of lesions treated with surgical excision (5/12) showed no recurrence or metastasis within the follow-up periods reported in the respective studies. However, in the single MMS case that did recur, the authors noted the possibility of a separate tumor within the area, indicating a multifocal malignancy.
This study is limited by the lack of information regarding the margin sizes of excisions, reporting bias, and the small sample size due to the rarity of these tumors.
MMS demonstrated a lower recurrence rate in the treatment of cylindrocarcinoma compared to surgical excision. Due to the importance of early surgical intervention and attaining clear margins, MMS should be considered a viable and effective treatment option for the treatment of cylindrocarcinoma.
Nguyen K, Chen A, Shalabi MMK, et al. Surgical outcomes of cylindrocarcinoma treated with Mohs micrographic surgery and excision: a systematic review. J Drugs Dermatol. 2025;24(5):444-446. doi:10.36849/JDD.8779.
圆柱瘤是一种良性附属器肿瘤，常与布鲁克-施皮格勒综合征和家族性圆柱瘤病等疾病相关。圆柱瘤可发生恶性转化为圆柱癌。虽然手术切除是圆柱癌的传统治疗方法，但莫氏显微描记手术（MMS）与手术切除在治疗效果和复发率方面的比较研究有限。
本研究旨在根据已发表的复发和转移数据，分析MMS和传统手术切除治疗圆柱癌的手术效果。
利用PubMed和SCOPUS进行系统综述，以确定从创刊至2024年5月期间涉及通过切除和/或MMS治疗圆柱癌的文章。检索词包括圆柱癌、恶性圆柱瘤和圆柱状癌。
我们识别出11篇文章，涵盖12例患者和18例手术。75%的MMS治疗（3/4）无复发，而在各自研究报告的随访期内，仅42%接受手术切除治疗的病变（5/12）无复发或转移。然而，在唯一复发的MMS病例中，作者指出该区域内可能存在另一个肿瘤，提示为多灶性恶性肿瘤。
本研究受到以下因素限制，即缺乏关于切除边缘大小的信息、报告偏倚以及由于这些肿瘤罕见导致样本量小。
与手术切除相比，MMS在治疗圆柱癌时显示出较低的复发率。鉴于早期手术干预和获得切缘阴性的重要性，MMS应被视为治疗圆柱癌的一种可行且有效的治疗选择。
Nguyen K, Chen A, Shalabi MMK,等。莫氏显微描记手术和切除治疗圆柱癌的手术效果：一项系统综述。《药物皮肤病学杂志》。2025;24(5):444 - 446。doi:10.3 / 6849 / JDD.8779。
