Arora Neha, Wittmer Ashley, Shalabi Mojahed Mohammad K, Jing Frank, Nadir Umer, Kelley Benjamin F, Tolkachjov Stanislav N
Texas A&M School of Medicine, Dallas, TX, USA.
Department of Dermatology, Baylor Scott & White Medical Center, Temple, TX, USA.
Arch Dermatol Res. 2025 Feb 1;317(1):335. doi: 10.1007/s00403-025-03842-7.
Adenoid cystic carcinoma (ACC) is a rare cancer that most commonly occurs in the salivary glands, making up approximately 2-4% of all head and neck malignancies. Treatment for ACC varies, with combinations of surgical excision, adjuvant radiotherapy, and chemotherapy reported in the literature. In this study, we aim to assess ACC recurrence rates with Mohs Micrographic Surgery (MMS) treatment compared to traditional wide local excision (WLE). In June of 2024, a comprehensive review of the literature was performed using the following keywords: "Adenoid Cystic Carcinoma" and/or "Mohs Micrographic Surgery" and/or "MMS" and/or "excision." Between the two databases, 25 articles were identified which included a total of 30 patients. Among all the articles, 30 procedures were documented - 8 MMS and 22 WLE. Patients with ACC treated with WLE had a higher rate of recurrence (40.9%) compared to those treated with MMS (12.5%). Limitations include a small number of tumors treated and reporting bias. MMS for the treatment of ACC demonstrated a decreased recurrence rate compared to WLE. Further studies with larger sample sizes are needed to confirm the benefit of MMS over WLE.
腺样囊性癌（ACC）是一种罕见的癌症，最常发生于唾液腺，约占所有头颈部恶性肿瘤的2%-4%。ACC的治疗方法各不相同，文献报道有手术切除、辅助放疗和化疗相结合的治疗方式。在本研究中，我们旨在评估与传统广泛局部切除（WLE）相比，采用莫氏显微外科手术（MMS）治疗ACC的复发率。2024年6月，使用以下关键词对文献进行了全面检索：“腺样囊性癌”和/或“莫氏显微外科手术”和/或“MMS”和/或“切除”。在两个数据库中，共识别出25篇文章，其中共有30例患者。在所有文章中，记录了30例手术——8例MMS和22例WLE。与接受MMS治疗的患者（12.5%）相比，接受WLE治疗的ACC患者复发率更高（40.9%）。局限性包括治疗的肿瘤数量较少和报告偏倚。与WLE相比，MMS治疗ACC的复发率有所降低。需要进一步开展更大样本量的研究来证实MMS相对于WLE的优势。
