Wan Gui, Gu Lingui, Chen Yangyang, Wang Yiqing, Sun Ye, Li Zhenwei, Ma Wenbin, Bao Xinjie, Wang Renzhi
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Nanomedicine (Lond). 2025 Jun;20(11):1299-1319. doi: 10.1080/17435889.2025.2501514. Epub 2025 May 6.
Stroke has brought about a poor quality of life for patients and a substantial societal burden with high morbidity and mortality. Thus, the efficient stroke treatment has always been the hot topic in the research of medicine. In the past decades, nanobiotechnologies, including natural exosomes and artificial nanomaterials, have been a focus of attention for stroke treatment due to their inherent advantages, such as facile blood - brain barrier traversal and high drug encapsulation efficiency. Recently, thanks to the rapid development of nanobiotechnologies, more and more efforts have been made to study the therapeutic effects of exosomes and artificial nanomaterials as well as relevant mechanisms in stroke treatment. Herein, from recent studies and articles, the application of natural exosomes and artificial nanomaterials in stroke treatment are summarized. And their prospects of clinical translation and future development are also discussed in further detail.
中风给患者带来了较差的生活质量，并因其高发病率和死亡率造成了巨大的社会负担。因此，有效的中风治疗一直是医学研究的热点话题。在过去几十年中，包括天然外泌体和人工纳米材料在内的纳米生物技术因其固有的优势，如易于穿越血脑屏障和高药物包封效率，一直是中风治疗的关注焦点。最近，由于纳米生物技术的快速发展，人们越来越努力地研究外泌体和人工纳米材料在中风治疗中的治疗效果及相关机制。在此，根据最近的研究和文章，总结了天然外泌体和人工纳米材料在中风治疗中的应用。并进一步详细讨论了它们临床转化的前景和未来发展。
