Bretscher Peter A
Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Open Biol. 2025 Jan;15(5):240392. doi: 10.1098/rsob.240392. Epub 2025 May 7.
Essential to much medical progress (for example, preventing AIDS, tuberculosis and cancer) is understanding how the class of immunity is controlled. Most envisage that pathogen- or danger-associated signals are critical. Many classical observations, particularly on the variables of immunization affecting the class of immunity generated, are paradoxical under this dominant view, and are therefore neglected. Among these is the role of antigen dose. Plausible strategies to prevent and treat AIDS, cancer and tuberculosis are based on such neglected observations. Many suggest that the information overload stultifies the canon, inhibiting progress. I illustrate here that seeking and resolving paradoxes can provide a different perspective from that of the dominant canon, opening vistas that address major issues pertinent to world health.
对于许多医学进步（例如预防艾滋病、结核病和癌症）而言，关键在于了解免疫类别是如何被控制的。大多数人设想病原体或危险相关信号至关重要。许多经典观察结果，特别是关于影响所产生免疫类别的免疫接种变量的观察结果，在这种主流观点下是自相矛盾的，因此被忽视了。其中包括抗原剂量的作用。预防和治疗艾滋病、癌症和结核病的合理策略正是基于这些被忽视的观察结果。许多人认为信息过载使准则变得僵化，阻碍了进步。我在此说明，寻找并解决矛盾之处可以提供与主流准则不同的视角，开辟解决与世界卫生相关重大问题的前景。
