Chehayeb Rachel Jaber, Odzer Nicole, Albany Roberta A, Ferrucci Leah, Sarpong Daniel, Perez-Escamilla Rafael, Lewis Jessica B, Phipps Amanda I, Meisner Allison, Pusztai Lajos
Yale University School of Medicine, New Haven, CT, USA.
Cancer-in-the-Know, Mt Penn, PA, USA.
NPJ Breast Cancer. 2025 May 7;11(1):40. doi: 10.1038/s41523-025-00755-6.
Rates of triple negative breast cancer (TNBC) are higher in Black women than in non-Hispanic White women. Breastfeeding duration and younger age at first birth are known risk factors for TNBC and vary by race. To quantify the contribution of these risk factors to disparities in TNBC, we calculated the population-attributable fraction (PAF). A PubMed search was performed to identify relevant studies and pooled odds ratios for breastfeeding for < 6 months and age at first birth < 25 years were calculated. PAF was calculated using the Levin formula. PAF of breastfeeding for < 6 months was 12% (95% confidence interval (CI) 5-20%) among White women and 15% (95%CI 3-26%) among Black women. We estimate that up to 15% of annual new TNBC in Black women and 12% in White women might be avoided by supporting breastfeeding. Policies supporting breastfeeding could hence reduce TNBC incidence and lessen racial disparities.
黑人女性中三阴性乳腺癌（TNBC）的发病率高于非西班牙裔白人女性。母乳喂养持续时间和首次生育时年龄较小是已知的TNBC风险因素，且因种族而异。为了量化这些风险因素对TNBC差异的影响，我们计算了人群归因分数（PAF）。通过PubMed检索来识别相关研究，并计算母乳喂养<6个月和首次生育年龄<25岁的合并比值比。使用Levin公式计算PAF。白人女性中母乳喂养<6个月的PAF为12%（95%置信区间（CI）5-20%），黑人女性中为15%（95%CI 3-26%）。我们估计，通过支持母乳喂养，黑人女性每年新增TNBC病例中高达15%、白人女性中12%的病例可能得以避免。因此，支持母乳喂养的政策可以降低TNBC发病率并减少种族差异。
