Zhu Lili, Yuan Xiaofeng
Department of Infection Management, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Department of Spine Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Sci Rep. 2025 May 6;15(1):15817. doi: 10.1038/s41598-025-00885-8.
Osteoporosis, a skeletal disorder that reduces bone density, is a significant health concern. Alcohol dependence, a chronic condition, exacerbates public health problems due to its widespread occurrence and association with various comorbidities, including depression. This study aims to explore the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and lumbar bone mineral density (BMD)in individuals with alcohol dependence and depression. From 2009 to 2018, 49,693 participants were enrolled, and after screening, the study included 2,055 individuals with alcohol-dependency and depression. In this study, multivariate regression analysis was employed to assess the association between monocyte to HDL-C ratio and lumbar bone mineral density. Additionally, we conducted interaction tests and subgroup analysis. The result showed a negative correlation between MHR and lumbar BMD, which remained significant even after adjusting for covariates. Individuals with less than a 9th-grade education showed a positive link with MHR, while those with a college degree or higher had a negative link. This relationship remained significant in the fully adjusted model. A U-shaped relationship between MHR and lumbar BMD was observed in individuals with a high school diploma/GED, after adjusting for various factors. The intricate correlation between MHR and lumbar BMD may suggest the presence of biological interplays and disparities in socioeconomic or behavioral aspects. This underscores the necessity for tailored public health strategies that cater to various educational demographics.
骨质疏松症是一种降低骨密度的骨骼疾病，是一个重大的健康问题。酒精依赖是一种慢性疾病，由于其广泛存在并与包括抑郁症在内的各种合并症相关联，加剧了公共卫生问题。本研究旨在探讨酒精依赖和抑郁症患者单核细胞与高密度脂蛋白胆固醇比值（MHR）与腰椎骨密度（BMD）之间的关系。2009年至2018年，共招募了49693名参与者，经过筛选，该研究纳入了2055名酒精依赖和抑郁症患者。在本研究中，采用多变量回归分析来评估单核细胞与HDL-C比值与腰椎骨密度之间的关联。此外，我们还进行了交互作用检验和亚组分析。结果显示MHR与腰椎BMD呈负相关，即使在调整协变量后仍具有显著性。受教育程度低于九年级的个体与MHR呈正相关，而大学学历或更高学历的个体则呈负相关。在完全调整模型中，这种关系仍然显著。在调整各种因素后，高中文凭/同等学历的个体中观察到MHR与腰椎BMD之间呈U形关系。MHR与腰椎BMD之间复杂的相关性可能表明存在生物学相互作用以及社会经济或行为方面的差异。这凸显了制定针对不同教育人群的公共卫生策略的必要性。
