Department of Orthopedic, Guangdong, Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Front Endocrinol (Lausanne). 2024 Jun 7;15:1408467. doi: 10.3389/fendo.2024.1408467. eCollection 2024.
In China, osteoporosis has become a major health concern among elderly population, imposing significant burden on the country's social and economic systems. The monocyte to high-density lipoprotein ratio (MHR) has been currently recommended as a novel marker of inflammation and oxidative stress associated with osteoporosis in type 2 diabetes mellitus (T2DM). However, its reliability in non-diabetic elderly populations remains unclear. The present study was to evaluate the association between MHR and osteoporosis in a non-diabetic elderly population.
The clinical data of 240 non-diabetic elderly subjects (115 in the osteoporosis group and 125 in the normal bone group) were retrospectively analyzed and all statistical analyses were performed by using SPSS 26.0.
Differences in age, neutrophils, lymphocytes, monocytes, MHR, uric acid, creatinine, triglycerides,and high-density lipoprotein cholesterol were found to be statistically significant between the two groups. A binary logistic regression model was conducted by including age, MHR, UA and Cr as variables. The results showed that age was an independent risk factor and MHR was an independent protective factor for bone abnormality in the non-diabetic elderly population. The ROC analysis showed that the area under the curve for the predictive effect of MHR, age and their combined test on osteoporosis in non-diabetic elderly populations was 0.623, 0.728 and 0.761, respectively; the correlation analysis showed that MHR was positively correlated with lumbar and hip BMD, and negatively associated with femoral neck stress ratio, femoral intertrochanteric stress ratio, and femoral stem stress ratio, showing statistically significant differences (P<0.05).
For the non-diabetic elderly population: the MHR is a protective factor against bone abnormalities and was significantly higher in the normal bone group than in the abnormal bone group.
在中国，骨质疏松症已成为老年人群的主要健康问题，给国家的社会和经济系统带来了重大负担。单核细胞与高密度脂蛋白比值（MHR）目前被推荐为 2 型糖尿病（T2DM）相关炎症和氧化应激的新型标志物。然而，其在非糖尿病老年人群中的可靠性尚不清楚。本研究旨在评估 MHR 与非糖尿病老年人群骨质疏松症之间的关系。
回顾性分析 240 例非糖尿病老年患者（骨质疏松组 115 例，正常骨组 125 例）的临床资料，所有统计分析均采用 SPSS 26.0 进行。
两组间年龄、中性粒细胞、淋巴细胞、单核细胞、MHR、尿酸、肌酐、甘油三酯和高密度脂蛋白胆固醇差异有统计学意义。通过纳入年龄、MHR、UA 和 Cr 作为变量，进行二元逻辑回归模型分析。结果表明，年龄是骨异常的独立危险因素，MHR 是非糖尿病老年人群骨异常的独立保护因素。ROC 分析显示，MHR、年龄及其联合检验对非糖尿病老年人群骨质疏松症的预测效果的曲线下面积分别为 0.623、0.728 和 0.761；相关性分析显示，MHR 与腰椎和髋部 BMD 呈正相关，与股骨颈应力度、股骨粗隆间应力度和股骨干应力度呈负相关，差异均有统计学意义（P<0.05）。
对于非糖尿病老年人群：MHR 是骨异常的保护因素，在正常骨组中明显高于异常骨组。
