Rapapa Kamoho Alphonce, Deng Yujie, Peng Yongzhen, Ni Jianping, Pan Faming
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
Sci Rep. 2025 May 6;15(1):15755. doi: 10.1038/s41598-025-99274-4.
Ankylosing spondylitis (AS) is a prevalent type of arthritis presented by inflammation in the vertebrae joints accounting for high disability and morbidity rates globally. Although there is limited research exploring efficient diagnostic tools for this condition, a timely and precise diagnosis is required. This case-control study aimed to examine the association and clinical significance of inflammatory markers derived from whole blood cell count when used as indicators of AS and to assess the reliability of these indicators in a clinical setting. A logistic regression was conducted to evaluate the diagnostic potential of inflammatory biomarkers when used independently and in combination with other indices. Pearson's correlation test was used to analyze normally distributed data and Spearman's correlation coefficient was used for non-normally distributed data. A total of 171 AS patients were included in this study. There was no statistical difference in age between the groups (P > 0.05). There were significant variations in the following counts among groups counts: SII, WBC, RDW, ESR, CRP, neutrophil, lymphocyte, platelet, dNLR, and MLR, counts (P < 0.05), with WBC, CRP, ESR, platelets, lymphocyte, neutrophils, dNLR, MLR, and SII being significantly elevated in the AS patients group (P < 0.05). Based on the BASDAI score, 45 patients were assigned to the active group and 126 patients to the remission group. These two groups showed no statistical difference regarding age, RDW, WBC, platelets, neutrophils, monocytes, PLR, and dNLR (P > 0.05). SIRI, NLR, PLR, dNLR, NMLR, and SII may serve as valuable biomarkers of AS in a clinical setting.
强直性脊柱炎（AS）是一种常见的关节炎类型，表现为脊椎关节炎症，在全球范围内导致较高的残疾率和发病率。尽管针对这种疾病探索有效诊断工具的研究有限，但仍需要及时、准确的诊断。本病例对照研究旨在探讨全血细胞计数衍生的炎症标志物作为AS指标的相关性及临床意义，并评估这些指标在临床环境中的可靠性。进行逻辑回归以评估炎症生物标志物单独使用以及与其他指标联合使用时的诊断潜力。使用Pearson相关检验分析正态分布数据，使用Spearman相关系数分析非正态分布数据。本研究共纳入171例AS患者。两组之间年龄无统计学差异（P>0.05）。各分组之间以下计数存在显著差异：全身免疫炎症指数（SII）、白细胞（WBC）、红细胞分布宽度（RDW）、红细胞沉降率（ESR）、C反应蛋白（CRP）、中性粒细胞、淋巴细胞、血小板、中性粒细胞与淋巴细胞比值（dNLR）和单核细胞与淋巴细胞比值（MLR）计数（P<0.05），AS患者组的WBC、CRP、ESR、血小板、淋巴细胞、中性粒细胞、dNLR、MLR和SII显著升高（P<0.05）。根据巴斯强直性脊柱炎疾病活动指数（BASDAI）评分，45例患者被分配到活动组，126例患者被分配到缓解组。这两组在年龄、RDW、WBC、血小板、中性粒细胞、单核细胞、血小板与淋巴细胞比值（PLR）和dNLR方面无统计学差异（P>0.05）。全身免疫炎症反应指数（SIRI）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、中性粒细胞与淋巴细胞比值（dNLR）、中性粒细胞与单核细胞比值（NMLR）和全身免疫炎症指数（SII）可能在临床环境中作为AS的有价值生物标志物。
