University of Health Sciences, Department of Ophthalmology Ataşehir, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy mahallesi Hastane sokak No: 1/8, Istanbul 34752, Türkiye.
University of Health Sciences, Department of Ophthalmology Ataşehir, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy mahallesi Hastane sokak No: 1/8, Istanbul 34752, Türkiye.
Photodiagnosis Photodyn Ther. 2023 Jun;42:103552. doi: 10.1016/j.pdpdt.2023.103552. Epub 2023 Apr 4.
Central serous chorioretinopathy (CSCR) is the fourth most common retinopathy that causes severe vision loss and is frequently seen in young and active patients. Our aim in this study is to evaluate whether a foresight about the prognosis of patients with CSCR can be obtained by optical coherence tomography (OCT) findings.
Patients diagnosed with chronic CSCR at Fatih Sultan Mehmet Research and Training Hospital, Ophthalmology Department, were screened between January 2017 and September 2019, and 30 patients were included in the study. The anatomical and functional changes of the patients during the 6-month follow-up and the relationship between the OCT findings at baseline and the best corrected visual acuity (BCVA) in the sixth month were evaluated.
All of the participants were treated with subthreshold micropulse laser therapy. BCVA increased significantly at first month and sixth month examinations compared to baseline, while the central macular thicknesses decreased significantly (p = 0.01, p = 0.00). Among the parameters examined in the baseline OCT, a positive correlation was found between the thickness of the outer nuclear layer (r = -0.520, p = 0.003) and BCVA at sixth month. In addition, subretinal fluid density and the number of intra-subretinal hyperreflective dots negatively affected BCVA (r = 0.371, p = 0.044 and r = 0.509, p = 0.004).
Outer nuclear layer thickness, subretinal fluid density and intra-subretinal hyperreflective dots were the OCT biomarkers related to sixth month BCVA. The clinical use of these biomarkers will help evaluate the prognosis of the CSCR.
中心性浆液性脉络膜视网膜病变（CSCR）是第四种最常见的致盲性视网膜疾病，常发生于年轻且活跃的患者。本研究旨在通过光学相干断层扫描（OCT）结果评估 CSCR 患者的预后是否可以预测。
2017 年 1 月至 2019 年 9 月，在法提赫苏丹穆罕默德研究与培训医院眼科筛选出患有慢性 CSCR 的患者，并对 30 名患者进行了研究。评估了患者在 6 个月随访期间的解剖学和功能变化，以及基线时的 OCT 结果与第 6 个月最佳矫正视力（BCVA）之间的关系。
所有患者均接受阈下微脉冲激光治疗。与基线相比，第 1 个月和第 6 个月的 BCVA 显著增加，而中央黄斑厚度明显降低（p=0.01，p=0.00）。在基线 OCT 检查的参数中，外层核层厚度（r=-0.520，p=0.003）与第 6 个月的 BCVA 呈正相关。此外，视网膜下液密度和视网膜内高反射点的数量对 BCVA 有负面影响（r=0.371，p=0.044 和 r=0.509，p=0.004）。
外层核层厚度、视网膜下液密度和视网膜内高反射点是与第 6 个月 BCVA 相关的 OCT 生物标志物。这些生物标志物的临床应用将有助于评估 CSCR 的预后。
