Peer Nasheeta, Levitt Naomi, Lombard Carl, George Jaya, Kengne Andre-Pascal
Non-Communicable Diseases Research Unit, South African Medical Research Council, Durban and Cape Town, South Africa.
Department of Medicine, University of Cape Town (UCT), Cape Town, South Africa.
BMC Public Health. 2025 May 6;25(1):1674. doi: 10.1186/s12889-025-22307-0.
Globally, the prevalence of hypertension is high and rising; however, hypertension care remains suboptimal, including in South Africa. Therefore, the aim of this study was to determine the prevalence and associations of hypertension detection, treatment and control in > 21-year-old urban black residents with hypertension in Cape Town, South Africa.
In this randomly selected community-based cross-sectional study, data collection comprised administered questionnaires, clinical measurements and fasting biochemical analyses, including oral glucose tolerance tests. Hypertension was defined as blood pressure ≥ 140/90 mmHg or known hypertension on treatment. Separate logistic regression models evaluated the associations with hypertension detection, treatment and control. Each model included sociodemographic characteristics, problem drinking, daily tobacco smoking, family history of hypertension, obesity (body mass index ≥ 30 kg/m), and comorbidities of diabetes, high low-density lipoprotein cholesterol and chronic kidney disease (CKD).
Among 460 participants with hypertension, 65% were women and the mean age was 50.7 (SD ± 12.1) years. Prevalence of hypertension detection among participants with hypertension (62.4%), treatment among the detected (75.6%) and control among the treated (57.1%) were sub-optimal, with better rates in women (73.6%, 80.0%, 59.1%, respectively) than in men (41.6%, 61.2%, 48.8%) (p < 0.05 for detection and treatment). Hypertension detection among participants with hypertension was associated with age ≥ 45 years, female gender (OR: 3.56, 95%CI: 1.94-6.55), a family history of hypertension (OR: 1.81, 95% CI: 1.09-3.00), ≤ 7 years of education (OR: 1.76, 95%CI: 1.02-3.03), ≥ 50% of life spent in city (OR: 1.82, 95%CI: 1.07-3.10) and comorbid diabetes (OR: 3.51, 95%CI: 1.80-6.86) or CKD (OR: 6.27, 95%CI: 1.31-30.10). The poorest participants were half as likely as their counterparts to have their hypertension detected (OR: 0.51, 95%CI: 0.28-0.92). Treated hypertension in those detected was significantly associated with female gender (OR: 3.29, 95% CI: 1.42-7.67) and just missed being associated with comorbid diabetes (OR: 2.00, 95% CI: 0.99-4.03). Hypertension control among participants who were treated was significantly associated with female gender (OR: 2.36, 95%CI: 1.01-5.51) in the logistic regression analyses.
Participants who were female and with comorbid diabetes were more likely to have better hypertension care overall, while the poorest and less urbanised participants were less likely to have their hypertension detected. Strategies are required to ensure equitable distribution of hypertension care. In-depth research is required to understand the contributors to suboptimal hypertension care, which likely differ by age, gender, socioeconomic status and level of care.
在全球范围内,高血压患病率居高不下且呈上升趋势;然而,高血压护理仍不尽人意,在南非亦是如此。因此,本研究旨在确定南非开普敦21岁以上城市黑人高血压患者中高血压的检出率、治疗率及控制率,并分析其相关因素。
在这项随机抽取的基于社区的横断面研究中,数据收集包括问卷调查、临床测量和空腹生化分析,其中包括口服葡萄糖耐量试验。高血压定义为血压≥140/90 mmHg或正在接受治疗的已知高血压患者。采用单独的逻辑回归模型评估与高血压检出、治疗及控制的相关性。每个模型均纳入社会人口学特征、问题饮酒、每日吸烟、高血压家族史、肥胖(体重指数≥30 kg/m²)以及糖尿病、高低密度脂蛋白胆固醇和慢性肾脏病(CKD)等合并症。
在460例高血压患者中,65%为女性,平均年龄为50.7(标准差±12.1)岁。高血压患者的高血压检出率(62.4%)、已检出患者的治疗率(75.6%)和已治疗患者的控制率(57.1%)均未达到理想水平,女性的各项比率(分别为73.6%、80.0%、59.1%)高于男性(分别为41.6%、61.2%、48.8%)(检出率和治疗率的p<0.05)。高血压患者的高血压检出与年龄≥45岁、女性(比值比:3.56,95%置信区间:1.94 - 6.55)、高血压家族史(比值比:1.81,95%置信区间:1.09 - 3.00)、受教育年限≤7年(比值比:1.76,95%置信区间:1.02 - 3.03)、在城市生活≥50%的时间(比值比:1.82,95%置信区间:1.07 - 3.10)以及合并糖尿病(比值比:3.51,95%置信区间:1.80 - 6.86)或CKD(比值比:6.27,95%置信区间:1.31 - 30.10)相关。最贫困的参与者被检出高血压的可能性仅为其他参与者的一半(比值比:0.51,95%置信区间:0.28 - 0.92)。已检出患者的高血压治疗与女性性别显著相关(比值比:3.29,95%置信区间:1.42 - 7.67),与合并糖尿病的相关性接近显著(比值比:2.00,95%置信区间:0.99 - 4.03)。在逻辑回归分析中,已治疗患者的高血压控制与女性性别显著相关(比值比:2.36,95%置信区间:1.01 - 5.51)。
女性和合并糖尿病的参与者总体上更有可能获得更好的高血压护理,而最贫困和城市化程度较低的参与者被检出高血压的可能性较小。需要制定策略以确保高血压护理的公平分配。需要进行深入研究以了解导致高血压护理欠佳的因素,这些因素可能因年龄、性别、社会经济地位和护理水平而异。