Wang Tianzi, Liu Chang, Hu Xuefeng, Yang Ning, Qiu Chen
Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China.
Cancer Biol Med. 2025 May 6;22(5):439-59. doi: 10.20892/j.issn.2095-3941.2024.0589.
Senescent macrophages have emerged as dynamic cells within the tumor microenvironment that significantly promote tumor progression through complex cellular and molecular functional alterations. This review explores the multifaceted roles of macrophage senescence in cancer, and establishes links between senescent macrophages and tumor progression from multiple perspectives, on the basis of the first comprehensive analysis of the molecular mechanisms and pathways involved. By systematically examining the diverse changes in senescent macrophages, this review integrates and analyzes their effects on tumors, thus offering a comprehensive and novel theoretical foundation, and practical insights for cancer treatment. Notably, by integrating current molecular research and therapeutic advancements, we summarize novel therapeutic strategies targeting senescent macrophages, including senolytics, senescence modulators, and cutting-edge immunotherapies, thereby highlighting the potential of senescent macrophages as a therapeutic target and introducing new opportunities for cancer treatment.
衰老巨噬细胞已成为肿瘤微环境中的动态细胞，通过复杂的细胞和分子功能改变显著促进肿瘤进展。本综述探讨了巨噬细胞衰老在癌症中的多方面作用，并在首次全面分析相关分子机制和途径的基础上，从多个角度建立衰老巨噬细胞与肿瘤进展之间的联系。通过系统研究衰老巨噬细胞的各种变化，本综述整合并分析了它们对肿瘤的影响，从而为癌症治疗提供了全面而新颖的理论基础和实践见解。值得注意的是，通过整合当前的分子研究和治疗进展，我们总结了针对衰老巨噬细胞的新型治疗策略，包括衰老细胞溶解剂、衰老调节剂和前沿免疫疗法，从而突出了衰老巨噬细胞作为治疗靶点的潜力，并为癌症治疗带来了新机遇。
