针对衰老肿瘤微环境的免疫治疗策略。
Immune therapeutic strategies for the senescent tumor microenvironment.
作者信息
Yasuda Tadahito, Alan Wang Y
机构信息
Brown Center for Immunotherapy, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.
Indiana University Melvin and Bren Simon Comprehensive Cancer Center Indianapolis, Indianapolis, USA.
出版信息
Br J Cancer. 2025 Feb;132(3):237-244. doi: 10.1038/s41416-024-02865-7. Epub 2024 Oct 28.
Abstract
Senescent cells can either to promote immunosuppressive tumor microenvironment or facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy, durable responses in solid tumors, particularly in advanced stages, remain limited. Recent studies have shed light on the influence of senescent status within the tumor microenvironment (TME) on therapy resistance and major efforts are needed to overcome these challenges. This review summarizes recent advancements in targeting cellular senescence, with a particular focus on immunomodulatory approaches on the hallmarks of cellular senescence.
摘要
衰老细胞既可以促进免疫抑制性肿瘤微环境，也可以促进免疫监视。尽管癌症免疫疗法产生了革命性影响，但实体瘤尤其是晚期实体瘤的持久反应仍然有限。最近的研究揭示了肿瘤微环境（TME）中衰老状态对治疗耐药性的影响，需要付出巨大努力来克服这些挑战。本综述总结了靶向细胞衰老的最新进展，特别关注针对细胞衰老特征的免疫调节方法。
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