Giraldi T, Nisi C, Sava G
J Natl Cancer Inst. 1977 Apr;58(4):1129-30. doi: 10.1093/jnci/58.4.1129.
When three diazoacetyl-glycine derivatives, N-diazoacetyl-glycine amide (DGA), N-diazoacetyl-glycine hydrazide (DGI), and N-diazoacetyl-glycine ethyl ester (DGE), were tested against Lewis lung carcinoma in C57BL mice, DGA reduced sharply the number and weight of pulmonary metastases; the effects of DGI and DGE were less pronounced. The growth of the primary tumor was reduced slightly by DGA, but the greater effect was produced by DGI. The absence of correlation between the reduction of the growth of the primary implant and the number of lung secondary tumors for the tested compounds indicated that DGA possesses antimetastatic properties.
当三种重氮乙酰甘氨酸衍生物，即N-重氮乙酰甘氨酸酰胺（DGA）、N-重氮乙酰甘氨酸酰肼（DGI）和N-重氮乙酰甘氨酸乙酯（DGE），在C57BL小鼠身上针对Lewis肺癌进行测试时，DGA显著减少了肺转移灶的数量和重量；DGI和DGE的效果则不太明显。DGA使原发肿瘤的生长略有减少，但DGI产生的效果更显著。对于所测试的化合物，原发植入瘤生长的减少与肺继发性肿瘤数量之间缺乏相关性，这表明DGA具有抗转移特性。
