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Synthesis and in vitro cytotoxic activity of new n-diazoacetylglycine derivatives.

作者信息

Loggia R D, Furlani A, Savastano F, Scarcia V

出版信息

Experientia. 1976 May 15;32(5):636-8. doi: 10.1007/BF01990207.

DOI:10.1007/BF01990207
PMID:819289
Abstract

The syntheses of various N-diazoacetylglycine derivatives are described. The results of an in vitro screening carried out on KB cells for cytotoxic activity are reported. The most active compounds are DGE, DGiBA and DGHA. A possible relationship between the activity and the liposolubility of these compounds is discussed.

摘要

相似文献

1
Synthesis and in vitro cytotoxic activity of new n-diazoacetylglycine derivatives.
Experientia. 1976 May 15;32(5):636-8. doi: 10.1007/BF01990207.
2
Antitumor activity of N-diazoacetyl derivatives of glycine and phenylalanine against P388 leukemia and B16 melanoma in mice.甘氨酸和苯丙氨酸的N-重氮乙酰基衍生物对小鼠P388白血病和B16黑色素瘤的抗肿瘤活性。
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[Diazo derivatives of amino acids and peptides as possible antineoplastic chemotherapeutic agents. VI. Experimental anticancerigenic activity of diazoacetylglycine hydrazide].[氨基酸和肽的重氮衍生物作为潜在的抗肿瘤化疗药物。VI. 重氮乙酰甘氨酸酰肼的实验抗癌活性]
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Eur J Cancer (1965). 1979 Apr;15(4):603-7. doi: 10.1016/0014-2964(79)90098-7.
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Mechanism of the mutagenic activity of diazoacetylglycine derivatives.
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Damage and repair of DNA in cultured mammalian cells with N-diazoacetylglycine amide.用N-重氮乙酰甘氨酸酰胺研究培养的哺乳动物细胞中DNA的损伤与修复
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引用本文的文献

1
DNA damage and repair induced by diazoacetyl derivatives of amino acids with different mechanism of cytotoxicity. Correlations with mutagenicity and carcinogenicity.具有不同细胞毒性机制的氨基酸重氮乙酰基衍生物诱导的DNA损伤与修复。与致突变性和致癌性的相关性。
J Cancer Res Clin Oncol. 1979 May 14;94(1):7-20. doi: 10.1007/BF00405345.

本文引用的文献

1
Mutagenic activity of diazoacetylglycine derivatives.重氮乙酰甘氨酸衍生物的诱变活性。
Antimicrob Agents Chemother. 1974 Nov;6(5):655-6. doi: 10.1128/AAC.6.5.655.
2
Nutrition needs of mammalian cells in tissue culture.组织培养中哺乳动物细胞的营养需求。
Science. 1955 Sep 16;122(3168):501-14. doi: 10.1126/science.122.3168.501.
3
Propagation in a fluid medium of a human epidermoid carcinoma, strain KB.人表皮样癌KB株在流体介质中的增殖
Proc Soc Exp Biol Med. 1955 Jul;89(3):362-4. doi: 10.3181/00379727-89-21811.
4
Sequence peptide polymers. I. Polymers based on aspartic acid and glycine.序列肽聚合物。I. 基于天冬氨酸和甘氨酸的聚合物。
J Am Chem Soc. 1967 Feb 15;89(4):988-98. doi: 10.1021/ja00980a042.
5
Antineoplastic activity of diazoacetyl-glycine derivatives.重氮乙酰甘氨酸衍生物的抗肿瘤活性。
Cancer Res. 1966 Aug;26(8):1754-8.
6
Effect of N-diazoacetylglycine amide on the immune response of mice to sheep red blood cells.N-重氮乙酰甘氨酸酰胺对小鼠针对绵羊红细胞的免疫反应的影响。
Transplantation. 1972 Mar;13(3):224-8. doi: 10.1097/00007890-197203000-00004.
7
The immunodepressive activity of N-diazoacetylglycine amide in some transplantation systems.
Transplantation. 1970 Jul;10(1):100-5. doi: 10.1097/00007890-197007000-00011.
8
Effects of diazoacetyl-glycine amide on purine nucleotide metabolism in Ehrlich ascites tumour cells.重氮乙酰甘氨酸酰胺对艾氏腹水瘤细胞嘌呤核苷酸代谢的影响。
Biochem Pharmacol. 1974 Jan 15;23(2):289-93. doi: 10.1016/0006-2952(74)90419-5.
9
Effects of diazoacetyl-glycine amide on purine nucleotide and deoxyribonucleic acid synthesis in Ehrlich ascites tumor cells.重氮乙酰甘氨酸酰胺对艾氏腹水瘤细胞中嘌呤核苷酸和脱氧核糖核酸合成的影响。
Biochem Pharmacol. 1972 Nov 15;21(22):3035-9. doi: 10.1016/0006-2952(72)90195-5.
10
Effects of some N-diazoacetyl-glycine derivatives on the growth of E. coli.
Experientia. 1974 May 15;30(5):496-7. doi: 10.1007/BF01926314.